Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
View Patent ↗A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.
1. A method of manufacturing a sustained drug delivery system, comprising
positioning a drug core in an impermeable tube, said drug core containing a therapeutically effective amount of an active agent, wherein said impermeable tube is dimensionally stable and capable of supporting its own weight;
cross-sectionally cutting the tube into sections; and
forming a permeable outer layer around at least a portion of a section.
2. The method according to claim 1 , wherein the outer layer is formed by dipping, dropping, spraying, or brushing the section with a solution of polymer.
3. The method according to claim 1 , further comprising positioning an end member to said tube to form a closed-end tube, said end member selected from an impermeable cap and a permeable plug.
4. A method in accordance with claim 3 , wherein positioning an end member comprises joining said end member to a length of said tube to form a vessel-shaped member.
5. A method in accordance with claim 4 , wherein said joining comprises coupling an impermeable cap to said length of tube.
6. The method of claim 1 , wherein the active agent is fluocinolone acetonide.