Sterically hindered poly(ethylene glycol) alkanoic acids and derivatives thereof
View Patent ↗The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
1. A method comprising precipitating a polymer having the structure:
wherein:
R is a central core molecule;
POLY is a water-soluble and non-peptidic polymer backbone;
Q is O or S;
m is 1 to about 20;
Z is selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; and
X is a leaving group; and
q is an integer from 2 to about 300; and
wherein said precipitating is effected by use of a solvent in which the polymer is essentially insoluble.
2. The method of claim 1 , wherein R is glycerol residue.
3. The method of claim 1 , wherein R is a pentaerythritol residue.
4. The method of claim 1 , wherein q is 8.
5. The method of claim 1 , wherein POLY is poly(ethylene glycol).
6. The method of claim 5 , wherein the poly(ethylene glycol) has an average molecular weight from about 200 Da to about 100,000 Da.
7. The method of claim 1 , wherein Z is a C 1 -C 8 alkyl or substituted alkyl.
8. The method of claim 1 , wherein Z is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, t-butyl, and benzyl.
9. The method of claim 1 , wherein m is 1 to about 10.
10. The method of claim 1 , wherein X is hydroxyl.
11. The method of claim 1 , wherein the solvent is ethyl ether.
12. The method of claim 1 , wherein the solvent is isopropranol.