Endoparasiticidal gel composition
View Patent ↗A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.
1. A method for the preparation of an endoparasiticidal gel composition comprising about 1.0% to 3.5% wt/wt of moxidectin; about 10.0% to 15.0% wt/wt of praziquantel; about 4.0% to 24.0% wt/wt of benzyl alcohol; about 1.0% to 34.0% wt/wt of ethanol; about 2.0% to 15.0% wt/wt of colloidal silicon dioxide; about 1.0% to 20.0% wt/wt of a surfactant; and about 35.0% to 61.0% wt/wt of an oil, which comprises the following steps:
a). dissolving a thickener in a mixture of benzyl alcohol and ethanol to form a solution A;
b). mixing an oil with praziquantel to form a suspension B:
c). admixing solution A with suspension B at temperatures ≦50° C. until a solution C which is homogeneous at room temperature is obtained;
d). admixing surfactant and optionally butylated hydroxytoluene with solution C to form solution D; and,
e). sequentially admixing moxidectin and colloidal silicon dioxide to solution D to form gel E, wherein gel E is a non-aqueous composition.
2. The method of claim 1 further comprising the step:
f). mixing get E under a vacuum to form a clear yellow endoparasiticidal gel composition that is essentially free of air.
3. The method according to claim 1 wherein the oil is propylene glycol dicaprylate/dicaprate and the thickener is ethyl cellulose.
4. The method according to claim 3 wherein the surfactant comprises a polyoxyethylene sorbitan ester.
5. The method according to claim 4 wherein said polyoxyethylene sorbitan ester is polysorbate 80.