Thiazoline and oxazoline derivatives and their methods of use

1. A method of treating a disorder or condition selected from the group consisting of attention deficit disorder, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, Pick's Disease and, dementia associated with Lewy bodies, , in a patient in need of such treatment, comprising administering a therapeutically effective amount of a compound of formula (IIA):

or a pharmaceutically acceptable salt, ester or amide thereof, wherein

n is 1 or 2;

R 1 , is hydrogen, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein the alkyl group, alkenyl, alkynyl, aryl, and heteroaryl groups are each substituted with 0, 1, 2 or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, carboxy, cyano, haloalkoxy, halo, hydroxyl, nitro, and R a R b N—;

L is C(O), C(S), S(O), or S(O) 2 ;

X is O or S;

Z is aryl, cycloalkyl, heteroaryl, heterocycle, R e R f N—, —R 3 or —OR 3 ;

R a and R b are each independently hydrogen, alkyl, alkylcarbonyl, arylalkyl, and heteroaryl;

R c and R d are each independently hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle, and heterocyclealkyl;

R e and R f are each independently hydrogen, alkyl, alkylcarbonyl, alkenyl, alkynyl, aryl, arylalkyl, aryl(hydroxyl)alkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocyclealkyl, heteroaryl, heteroaryl(hydroxyl)alkyl, heteroarylalkyl, or hydroxyalkyl, wherein the alkyl group and the alkyl of alkylcarbonyl is substituted with 0, 1, 2 , or 3 substituents selected from alkoxy, cyano, or halo;

R 3 is alkyl, alkenyl, alkynyl, arylalkyl, haloalkyl, haloalkenyl, or haloalkynyl;

and R 6 is alkyl, alkenyl, formyl, cyano, heteroaryl(hydroxyl)alkyl, or CH═N—(CH 2 ) b —OR g , wherein the alkyl group and the alkenyl group is substituted with 0, 1, 2 , or 3 substituents independently selected from the group consisting of alkoxy, alkoxycarbonyl, aryloxy, alkylcarbonyloxy, aryl, arylalkoxy, carboxy, cycloalkyl, cyano, halo, haloalkoxy, heteroaryl, heterocycle, hydroxyl, nitro, and R C R d N—;

h is 0, 2, or 3; and

R g is hydrogen or alkyl.

2. The method of claim 1 , wherein

R 1 is hydrogen;

L is C(O); and

X is S.

3. The method of claim 2 wherein

R 6 is alkyl, wherein the alkyl group is substituted with 1, 2, or 3 hydroxyl groups.

4. The method of claim 3 ,

wherein Z is a heterocycle represented by the formula R k R 1 N—, wherein R k and R 1 taken together with the nitrogen atom to which each is attached form a monocyclic heterocycle, a bicyclic heterocycle, a monocyclic heteroaryl, or a bicyclic heteroaryl, wherein each group is substituted with 0, 1, 2, or 3 substituents selected from halo, hydroxyl, aryl, and heteroaryl.

5. The method of claim 4 , wherein

Z is unsubstituted pyrrolidine or pyrrolidine substituted with fluoro.

6. The method of claim 2 , wherein

Z is —NR e R f ; and

R e and R f are each independently selected from hydrogen, alkyl, arylalkyl, aryl(hydroxyl)alkyl, heteroaryl, heteroaryl(hydroxyl)alkyl, heterocyclealkyl, and heteroarylalkyl.

7. The method of claim 6 , wherein

R e is hydrogen or alkyl; and

R f is arylalkyl, heterocyclealkyl, or heteroarylalkyl.

8. The method according to claim 1 , wherein the compound of formula (IIA) is selected from the group consisting of:

ethyl (2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenecarbamate;

methyl (2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidenecarbamate;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol- 5 -yl)- 5 -methyl-1,3-thiazol-2(3H)-ylidene]acetamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N,N-diethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N,N-diisopropylurea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]piperidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]cyclobutanecarboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2,2-dimethylpropanamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide;

4-chloro-N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]benzamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-oxazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-oxazol-2(3H)-ylidene]-N,N-dimethylthiourea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(pyrrolidin-1-ylmethyl)-1,3-thiazol-2(3H)-ylidene]acetamide;

N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]piperidine-1-carboxamide;

N,N-diethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-phenylurea;

N,N-dimethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]cyclobutanecarboxamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]cyclopropanecarboxamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]methanesulfonamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]ethanesulfonamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]propane-1-sulfonamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]benzenesulfonamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]thiophene-2-sulfonamide;

3-cyano-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]benzenesulfonamide;

3-methoxy-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]benzenesulfonamide;

3-chloro-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]benzenesulfonamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-isopropylurea;

N-(sec-butyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-(tert-butyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1-methylbutyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1,1-dimethylpropyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1,2-dimethylpropyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1-ethylpropyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(2-methoxy-1-methylethyl) urea;

N-cyclopentyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-ethyl-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-isopropyl-N-methylurea;

N-butyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-is obutyl-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(1,3-dioxolan-2-ylmethyl)-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methyl-N-(3-methylbutyl) urea;

N-butyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-ethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N,N-dipropylurea;

N,N-dibutyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2,5-dimethylpyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methylpiperidine-1-carboxamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(2-methoxyethyl)-N-methylurea;

N-benzyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiaz ol-2(3H)-ylidene]-N-ethylurea;

N-benzyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-isopropylurea;

N-benzyl-N-butul-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(2-hydroxyethyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1,1,3,3-tetramethylbutyl) urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-[(1R)-2-hydroxy-1-phenylethyl]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-[(1S)-2-hydroxy-1-phenylethyl]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-[(1S)-1-phenylethyl]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-[(1R)-1-phenylethyl]urea;

N-benzyl-N-(tert-butyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methylurea;

N-benzyl-N-(2-cyanoethyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]urea;

N-(3-chlorobenzyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(2-methoxybenzyl)-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(3-methoxybenzyl)-N-methylurea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-1,3-dihydro-2H-isoindole-2-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-3,4-dihydroisoquinoline-2(1H)-carboxamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-ethyl-N-(pyridin-4-ylmethyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1-phenylpropyl)urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-2,3-dihydro-1H-inden-1-ylurea;

N-(5-fluoro-2-phenoxybenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2-chloro-6-fluorobenzyl)-N-ethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-prop-2-ynylurea;

N-[4-(allyloxy)benzyl]-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-formyl-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-[(Z)-(hydroxyimino)methyl]-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(fluoromethyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-formyl-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

(3R)-3-fluoro-N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

(3S)-3-fluoro-N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[4-(difluoromethoxy)benzyl]-N-methyl-N′-[(2Z)- 5 -methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[1-(4-ethoxyphenyl)ethyl]-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N-[(6-methylpyridin-2-yl)methyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N-but-2-ynyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1-methyl-1-phenylethyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2-chlorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(thien-2-ylmethyl)urea;

N-(4-chlorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(3-chlorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[1-(methoxymethyl)propyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-cyclopentyl-N-(4-fluorobenzyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(1S)-2-hydroxy-1-phenylethyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1R)-1-phenylethyl]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N′-[(1S)-1-phenylethyl]urea;

(3R)-3-hydroxy-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-methyl-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(pyrazin-2-ylmethyl)urea;

N-[(2Z)-5-(methoxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-5-(ethoxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(ethoxymethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-{[(4-fluorophenyl) amino]methyl}-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5- {[(4-fluorophenyl) (methyl) amino]methyl}-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-2,3-dihydro-1H-inden-2-ylurea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-1H-imidazole-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-[1-(methoxymethyhpropy]urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-isobutyl-N-prop-2-ynylurea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]azetidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N′-(1-methyl-1-phenylethyl)urea;

N-cyclopropyl-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(2-fluorobenzyl) urea;

N-(2-chlorobenzyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methylurea;

N-(4-chlorobenzyl)-N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-(4-methoxybenzyl)-N-methylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methyl-N-(pyridin-2-ylmethyl)urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methyl-N-(pyridin-3-ylmethyl)urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-ethyl-N-(pyridin-3-ylmethyl) urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methyl-N-(pyridin-4-ylmethyl)urea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]-N-methyl-N-(pyrazin-2-ylmethyl)urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(pyridin-3-ylmethyl)urea;

N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylidene]acetamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxo 1 -5-yl)-5-methyl-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carb othioamide;

2-methyl-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylidene]indoline-1-carboxamide;

5-bromo-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]indoline-1-carboxamide;

N-methyl-N-[(1-methyl-1H-indo 1 -5-yl)-methyl]-N′-[(2Z)-5-methyl-3-2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(4-pyridin-4-ylbenzyl)urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-[(1R)-1-phenylethyl]urea;

2-(4-fluorophenyl)-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]indoline-1-carboxamide;

N-but-2-ynyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylidene]-N-phenylurea;

N-isobutyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benz odioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-prop-2-ynylurea;

N,N-dibut-2-ynyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-ethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(thien-2-ylmethyl)urea;

N-methyl-N-[(3-methylpyridin-2-yl)methyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N-[(3-methylpyridin-4-yl)methyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-2-pyridin-3-ylpyrrolidine-1-carboxamide;

N-(4-ethylbenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-ethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(pyridin-4-ylmethyl)urea;

N-(4-ethoxybenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N-(4-methylbenzyl)-′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1 ,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(4-bromobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(4-tert-butylbenzyl)-N-methyl-N′-[(2E)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(4-isopropylbenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(3,4-dichlorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2,4-dichlorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(4-fluorobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(4-methoxybenzyl)-N-methyl-N′-[(2Z)- 5 -methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(quinolin-6-ylmethyl)urea;

N-(3-bromobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2-bromobenzyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-[(pyridin-3-ylamino)methyl]-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(methoxymethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(isopropoxymethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-5-[(benzyoloxy)menthyl]-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-2,5-dihydro-1H-pyrrole-1-carboxamide;

(2S)-2-methyl-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-(1-cyclopropyl-1-methylethyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl-1,3-thiazol-2(3H)-ylidene]urea;

N-(1,3-dioxolan-2-ylmethyl)-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-cyano-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxyethyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxybutyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(1-hydroxy-2-methylpropyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5- {(E)-[(2-hydroxyethyl)imino]methyl}-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(hydroxymethyl)-4-pyridin-2-yl-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea compound with N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-[hydroxy (pyridin-2-yl) methyl]-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea (1:1);

N′-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(difluoromethyl)-1,3-thiazol-2(3H)-ylidene]-N,N-dimethylurea;

N-[(2Z)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-5-(fluoromethyl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

(3S)-3-hydroxy-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

2,2-dimethyl-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]propanamide;

3-methyl-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]butanamide;

N-[(2Z)-5-(cyanomethyl)-3-(2,2-difluoro-1,3-benzodioxol-5-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

(3R)-3-fluoro-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

(3S)-3-fluoro-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]pyrrolidine-1-carboxamide;

N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-2,2-dimethylpropanamide;

N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]benzamide;

N-[(2Z)-5-(hydroxymethyl)-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-1H-imidazole-1-carboxamide;

N-benzyl-N-(2-hydroxyethyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]indoline-1-carboxamide;

2-methyl-N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]piperidine-1-carboxamide;

N-(tert-butyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2-hydroxy-1,1-dimethylethyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1,1-dimethylprop-2-ynyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N′-(1,1,3,3-tetramethylbutyl)urea;

N-(1,1-dimethylpropyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1-ethyl-1-methylpropyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-(thieno[2,3-b]pyridin-2-ylmethyl)urea;

N-[(1R)-2-hydroxy-1-phenylethyl]-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1,2-dimethylpropyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-isopropyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(2-methoxy-1-methylethyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(sec-butyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1-ethylpropyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-(1-methylbutyl)-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]-N-prop-2-ynylurea;

N-benzyl-N-isopropyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-ethyl-N-methyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea;

N-benzyl-N-ethyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea; and

N-benzyl-N-butyl-N′-[(2Z)-5-methyl-3-(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-1,3-thiazol-2(3H)-ylidene]urea.

9. The method of claim 1 , wherein the disorder or condition is attention deficit hyperactivity disorders, comprising administering a compound of formula (IIA) in combination with a medication used in the treatment of attention deficit hyperactivity disorders.