IP Library › Granted Patent US 8,993,593
Granted Patent B2
US 8,993,593 · App. 12/698,070 · Granted Mar 31, 2015

N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators

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Quick Facts
Patent No.
US 8,993,593
App. No.
12/698,070
Granted
Mar 31, 2015
Kind
B2
Abstract

This invention provides a compound of formula A The compound provided herein can affect the opening of, or otherwise modulate, voltage-gated potassium channels. The compound provided herein is useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

Claims (2)

1. Compound A:

2. A method of treating seizure in a patient comprising administering the compound of claim 1 in an amount of from about 10 mg to about 2000 mg per day to a patient.

Assignments (14)
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY NAME COMMA INSIDE THE ASSIGNMENT DOCUMENT PREVIOUSLY RECORDED AT REEL: 042246 FRAME: 0703. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 1, 2018
From: 1ST ORDER PHARMACEUTICALS, INC.
To: XENON PHARMACEUTICALS INC.
Reel/Frame 046702/0926 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNMENT ITSELF WHICH WAS PREVIOUSLY ATTACHED TO ORIGINAL RECORDATION (BY REMOVING THE COMMA IN RECEIVING PARTY NAME) PREVIOUSLY RECORDED ON REEL 042246 FRAME 0654. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF THE ENTIRE RIGHT, TITLE AND INTEREST. Recorded Aug 1, 2018
From: 1ST ORDER PHARMACEUTICALS, INC.
To: XENON PHARMACEUTICALS INC.
Reel/Frame 047470/0813 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2017
From: 1ST ORDER PHARMACEUTICALS, INC.
To: XENON PHARMACEUTICALS INC.
Reel/Frame 042246/0703 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2017
From: 1ST ORDER PHARMACEUTICALS, INC.
To: XENON PHARMACEUTICALS INC.
Reel/Frame 042246/0654 →
RELEASE OF SECURITY INTEREST Recorded Mar 9, 2017
From: BARCLAYS BANK PLC
To: VALEANT PHARMACEUTICALS INTERNATIONAL
Reel/Frame 041925/0507 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2017
From: VALEANT PHARMACEUTICALS INTERNATIONAL
To: 1ST ORDER PHARMACEUTICALS, INC.
Reel/Frame 041273/0066 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2016
From: VALEANT PHARMACEUTICALS LUXEMBOURG S.AR.L.
To: 1ST ORDER PHARMACEUTICALS, INC.
Reel/Frame 038484/0945 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2016
From: VALEANT PHARMACEUTICALS INTERNATIONAL, INC.
To: VALEANT PHARMACEUTICALS LUXEMBOURG S.AR.L.
Reel/Frame 038484/0935 →
NOTICE OF SUCCESSION OF AGENCY Recorded Jan 9, 2015
From: GOLDMAN SACHS LENDING PARTNERS, LLC
To: BARCLAYS BANK PLC, AS SUCCESSOR AGENT
Reel/Frame 034749/0689 →
SECURITY AGREEMENT Recorded Jul 18, 2011
From: VALEANT PHARMACEUTICALS INTERNATIONAL, A DELAWARE CORPORATION; ATON PHARMA, INC., A DELAWARE CORPORATION; CORIA LABORATORIES, LTD., A DELAWARE CORPORATION; DOW PHARMACEUTICAL SCIENCES, INC., A DELAWARE CORPORATION; VALEANT PHARMACEUTICALS NORTH AMERICA LLC, A DELAWARE LLC; PRESTWICK PHARMACEUTICALS, INC., A DELAWARE CORPORATION; VALEANT BIOMEDICALS, INC., A DELAWARE CORPORATION
To: GOLDMAN SACHS LENDING PARTNERS LLC, AS COLLATERAL AGENT
Reel/Frame 026606/0061 →
PATENT SECURITY RELEASE AGREEMENT Recorded Mar 14, 2011
From: GOLDMAN SACHS LENDING PARTNERS LLC
To: VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS NORTH AMERICA; CORIA LABORATORIES, LTD.; DOW PHARMACEUTICAL SCIENCES, INC.; ATON PHARMA, INC.
Reel/Frame 025950/0048 →
SECURITY AGREEMENT Recorded Oct 4, 2010
From: ATON PHARMA, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA; VALEANT PHARMACEUTICALS INTERNATIONAL; CORIA LABORATORIES, LTD.; DOW PHARMACEUTICAL SCIENCES, INC.
To: GOLDMAN SACHS LENDING PARTNERS LLC, AS COLLATERAL AGENT
Reel/Frame 025084/0169 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2010
From: VERNIER, JEAN-MICHEL; DE LA ROSA, MARTHA ALICIA; CHEN, HUANMING; WU, JIM ZHEN; LARSON, GARY LEE; CHENEY, IAN WAYNE
To: VALEANT PHARMACEUTICALS INTERNATIONAL
Reel/Frame 024994/0912 →