6-aminoisoquinoline compounds
View Patent ↗6-Aminoisoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.
1. A method of treating a condition comprising administering to a subject in need of treatment a safe and effective amount of a compound according to Formula (I):
wherein A is —OCH 2 ;
wherein R 1 , and R 2 are hydrogen; and
wherein R 3 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, amino, cyano, cycloalkyl, heterocycloalkyl, aryl, C 1 -C 4 alkyl aryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonyl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl;
wherein the condition is eye disease.
2. The method of claim 1 , wherein the compound is selected from the following:
3. The method of claim 1 , wherein the compound has the structure
wherein R, R′, and R″ are, independently, hydrogen, halogen, C 1 -C 4 alkyl, alkoxy, phenoxy, —O—R 7 , amino, nitro, cyano, aryl, C 1 -C 4 alkylaryl, heteroaryl, C 1 -C 4 alkyl heteroaryl, carbonylamino, thioalkyl, sulfonyl, sulfonylamino, acyl, or carboxyl.
4. The method of claim 3 , wherein R is acyl, alkyl, C 1 -C 4 alkyl heteroaryl, C 1 -C 4 alkyl aryl or carbonylamino.