Truncated BAFF receptors
View Patent ↗The disclosure provides a non-naturally occurring BAFF-R glycoprotein having a deletion in the extracellular domain which results in an altered O-linked glycosylation pattern. The disclosure also provides methods and pharmaceutical compositions for treating B-cell- and T-cell-mediated disorders.
1. An isolated BAFF-R (BAFF receptor) polypeptide comprising amino acids 14 to 56 of SEQ ID NO:1 and having mutations at amino acids 50, 51, and 56 of SEQ ID NO:1, wherein amino acid 50 is not serine or threonine, amino acid 51 is not serine or threonine, and amino acid 56 is not serine or threonine.
2. An isolated BAFF-R (BAFF receptor) polypeptide comprising amino acids 14 to 63 of SEQ ID NO: 1 and having mutations at amino acids 50, 51, 56 and 63 of SEQ ID NO: 1, wherein amino acid 50 is not serine or threonine, amino acid 51 is not serine or threonine, amino acid 56 is not serine or threonine, and amino acid 63 is not serine or threonine.
3. An isolated BAFF-R (BAFF receptor) polypeptide comprising amino acids 14to 63 of SEQ ID NO: 1 and having mutations at amino acids 50, 51, and 56 of SEQ ID NO: 1, wherein amino acid 50 is not serine or threonine, amino acid 51 is not serine or threonine, and amino acid 56 is not serine or threonine.