Segmented delivery system
View Patent ↗A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
1. A delivery system comprising:
a plurality of operably linked segments comprising: a first segment and a second segment of a first type each comprising a flexible mesh covering material defining at least one compartment, the at least one compartment of the first segment of the first type retaining fully demineralized bone fibers therein and the at least one compartment of the second segment of the first type retaining surface demineralized bone chips therein, wherein said flexible mesh covering material comprises a biodegradable polymer, and a first segment of a second type, wherein the first segment of the second type operably links the first and second segments of the first type, and the second type is comprised of a covering material comprising a biodegradable mesh polymer.
2. The delivery system of claim 1 , wherein the first segment of the second type contains little or no fully demineralized bone fibers and surface demineralized bone chips.
3. The delivery system of claim 1 , wherein the delivery system is designed for use in a sternum closure procedure.
4. The delivery system of claim 1 , wherein the delivery system is used in filling an irregular shaped bone void.
5. The delivery system of claim 4 , wherein at least two segments of the first segment type within the bone void are packed substantially parallel.
6. The delivery system of claim 1 , wherein the delivery system is terminally sterilized.
7. The delivery system of claim 6 , wherein the delivery system is sterilized by a method chosen from the group consisting of: gamma radiation, electron beam radiation, UV irradiation, cobalt source radiation; autoclaving, dry heating, and by supercritical fluid exposure.
8. The delivery system of claim 7 , wherein the fully demineralized bone fibers and surface demineralized bone chips are sterilized by a method other than that used to sterilize the covering material.
9. The delivery system of claim 1 , wherein the biodegradable polymer covering comprises at least one of poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactic-co-glycolic acid) (PLGA) and polyhydroxyalkanoates.