Treatment of T-cell mediated diseases
View Patent ↗The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.
1. A method of reducing the severity and/or symptoms of multiple sclerosis comprising administering to an animal in need thereof an effective amount of a pharmaceutical composition comprising albumin and DA-DKP, wherein the DA-DKP was formed from the two N-terminal amino acids of the albumin.
2. The method of claim 1 wherein the pharmaceutical composition is administered orally.
3. The method of claim 1 wherein the animal is a human and the albumin is a human albumin.