Use of dams to improve yield in film processing
View Patent ↗The present invention relates to methods for forming films. In particular, the present invention relates to the formation of films on a substrate, the substrate having at least one dam portion.
1. A method of forming a film product, comprising the steps of:
a. Providing an embossed substrate having at least one confined region having a top surface and an outer region;
b. Depositing a wet film matrix comprising a medicament on said top surface of said confined region and excluding said wet film matrix from said outer region;
c. Drying said wet film matrix on said embossed substrate to form a dried film from which the medicament is mucosally absorbable: and
d. Finalizing said dried film;
wherein said dried film is adapted to be removed from the substrate prior to finalizing said dried film.
2. The method of claim 1 , wherein said substrate comprises plastic, paper, mylar, foil, and combinations thereof.
3. The method of claim 1 , wherein said confined region is defined on at least one side by a dam having a side wall.
4. The method of claim 1 , wherein said confined region comprises a channel having a first side and a second side.
5. The method of claim 4 , wherein said first side comprises a first dam and said second side comprise a second dam, said first and second dams each having a height which is higher than said top surface.
6. The method of claim 5 , wherein said confined region has a depth defined by the distance between said top surface and the height of said first dam.
7. The method of claim 6 , wherein said deposited wet film matrix has a depth substantially equal to the depth of said confined region.
8. The method of claim 6 , wherein said deposited wet film matrix has a depth less than the depth of said confined region.
9. The method of claim 6 , wherein said deposited wet film matrix has a depth higher than the depth of said confined region.
10. The method of claim 5 , wherein said first dam comprises a peaked configuration.
11. The method of claim 5 , wherein said first dam comprises a plateau configuration.
12. The method of claim 5 , wherein said first dam comprises a mesa configuration.
13. The method of claim 5 , wherein said first dam comprises a mound configuration.
14. The method of claim 1 , wherein said embossed substrate is capable of being rolled upon itself in such a manner that said confined region is nested within itself.
15. The method of claim 1 , wherein mucosally absorbable means absorbable through the oral, buccal, sublingual, vaginal, ocular, or anal areas of the body or though the tongue.
16. The method of claim 1 , wherein said finalizing said dried film is selected from the group consisting of cutting said dried film, sizing said dried film, printing on said dried film, packaging said dried film, distributing said dried film, administering said dried film, and combinations thereof.
17. The method of claim 1 , wherein said finalizing said dried film is packaging said dried film.
18. A method of forming a film product, comprising the steps of:
a. Providing a non-embossed substrate;
b. Embossing said non-embossed substrate to provide an embossed substrate having at least one confined region having a top surface and an outer region;
c. Depositing a wet film matrix comprising a medicament on said top surface of said confined region and excluding said wet film matrix from said outer region;
d. Drying said wet film matrix on said embossed substrate to form a dried film from which the medicament is mucosally absorbable; and
e. Finalizing said dried film;
wherein said dried film is adapted to be removed from the substrate prior to finalizing said dried film.
19. The method of claim 18 , wherein said substrate comprises plastic, paper, mylar, foil, and combinations thereof.
20. The method of claim 18 , wherein said step of embossing said non-embossed substrate comprises a step selected from the group consisting of extrusion, thermoforming, vacuum forming, cold forming, calender rolls, embossing rolls, and combinations thereof.
21. The method of claim 18 , wherein said confined region is defined on at least one side by a dam having a side wall.
22. The method of claim 18 , wherein said confined region comprises a channel having a first side and a second side.
23. The method of claim 22 , wherein said first side comprises a first dam and said second side comprise a second dam, said first and second dams each having a height which is higher than said top surface.
24. The method of claim 23 , wherein said confined region has a depth defined by the distance between said top surface and the height of said first dam.
25. The method of claim 24 , wherein said deposited wet film matrix has a depth substantially equal to the depth of said confined region.
26. The method of claim 24 , wherein said deposited wet film matrix has a depth less than the depth of said confined region.
27. The method of claim 24 , wherein said deposited wet film matrix has a depth higher than the depth of said confined region.
28. The method of claim 23 , wherein said first dam comprises a peaked configuration.
29. The method of claim 23 , wherein said first dam comprises a plateau configuration.
30. The method of claim 23 , wherein said first dam comprises a mesa configuration.
31. The method of claim 23 , wherein said first dam comprises a mound configuration.
32. The method of claim 18 , wherein said embossed substrate is capable of being rolled upon itself in such a manner that said confined region is nested within itself.
33. The method of claim 18 , wherein mucosally absorbable means absorbable through the oral, buccal, sublingual, vaginal, ocular, or anal areas of the body or though the tongue.
34. The method of claim 18 , wherein said finalizing said dried film is selected from the group consisting of cutting said dried film, sizing said dried film, printing on said dried film, packaging said dried film, distributing said dried film, administering said dried film, and combinations thereof.
35. The method of claim 18 , wherein said finalizing said dried film is packaging said dried film.
36. A method of continuously forming a film product, comprising the steps of:
a. Providing a non-embossed substrate having a starting edge;
b. Feeding said starting edge of said non-embossed substrate into a film-forming mechanism, such that said non-embossed substrate continuously moves through said film-forming mechanism;
c. Continuously embossing said non-embossed substrate as it moves through said film-forming mechanism to provide an embossed substrate having at least one confined region having a top surface and an outer region;
d. Continuously depositing a wet film matrix comprising a medicament on said top surface of said confined region and excluding said wet film matrix from said outer region as said embossed substrate moves through said film-forming mechanism;
e. Drying said wet film matrix on said embossed substrate to form a dried film from which the medicament is mucosally absorbable: and
f. Finalizing said dried film;
wherein said dried film is adapted to be removed from the substrate prior to finalizing said dried film.
37. The method of claim 36 , wherein said substrate comprises plastic, paper, mylar, foil, and combinations thereof.
38. The method of claim 36 , wherein said step of embossing said non-embossed substrate comprises a step selected from the group consisting of extrusion, thermoforming, vacuum forming, cold forming, calender rolls, embossing rolls.
39. The method of claim 36 , wherein said confined region is defined on at least one side by a dam having a side wall.
40. The method of claim 36 , wherein said confined region comprises a channel having a first side and a second side.
41. The method of claim 40 , wherein said first side comprises a first dam and said second side comprise a second dam, said first and second dams each having a height which is higher than said top surface.
42. The method of claim 41 , wherein said confined region has a depth defined by the distance between said top surface and the height of said first dam.
43. The method of claim 42 , wherein said deposited wet film matrix has a depth substantially equal to the depth of said confined region.
44. The method of claim 42 , wherein said deposited wet film matrix has a depth less than the depth of said confined region.
45. The method of claim 42 , wherein said deposited wet film matrix has a depth higher than the depth of said confined region.
46. The method of claim 41 , wherein said first dam comprises a peaked configuration.
47. The method of claim 41 , wherein said first dam comprises a plateau configuration.
48. The method of claim 36 , wherein said embossed substrate is capable of being rolled upon itself in such a manner that said confined region is nested within itself.
49. The method of claim 36 , wherein mucosally absorbable means absorbable through the oral, buccal, sublingual, vaginal, ocular, or anal areas of the body or though the tongue.
50. The method of claim 36 , wherein said finalizing said dried film is selected from the group consisting of cutting said dried film, sizing said dried film, printing on said dried film, packaging said dried film, distributing said dried film, administering said dried film, and combinations thereof.
51. The method of claim 36 , wherein said finalizing said dried film is packaging said dried film.