Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
View Patent ↗Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
1. A compound M″
2. A method for making the compound M″ according to claim 1 , the method comprising
(a) treating compound L
with hydrochloric acid to provide compound L′
(b) treating compound L′ with sodium hydroxide to provide compound M′
(c) treating compound M′ with water to provide compound M″.
3. The method according to claim 2 , wherein compound L is provided by a method comprising:
treating compound K
with trifluoroacetic anhydride in the presence of pyridine or triethylamine followed by treatment with a strong base to provide compound L.
4. The method according to claim 3 , wherein the strong base is sodium hydroxide, lithium hydroxide or potassium hydroxide.