Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
View Patent ↗The present invention provides arylpiperazine derivatives having Formula I which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.
1. A compound having the structure of Compound 14b, or a pharmaceutically acceptable salt thereof:
2. The compound of claim 1 , wherein the compound is in the form of a hydrochloride salt.
3. A compound having the structure of Compound 14b, or a pharmaceutically acceptable salt or isomer thereof:
wherein one or more hydrogens of the compound are optionally substituted with 2 H (deuterium).
4. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier, excipient, or diluent.
5. A method of treating psychoses, schizophrenia, acute mania, bipolar disorder, autistic disorder or depression, the method comprising administering to a patient in need thereof the pharmaceutical formulation according to claim 4 .
6. The method of claim 5 , wherein said method treats schizophrenia.
7. The method of claim 5 , wherein said method treats bipolar disorder.