IP Library › Granted Patent US 8,221,794
Granted Patent B2
US 8,221,794 · App. 12/716,854 · Granted Jul 17, 2012

Anti-angiogenic nanoparticle compositions

Assignee: Angiotech Pharmaceuticals, Inc.
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Quick Facts
Patent No.
US 8,221,794
App. No.
12/716,854
Granted
Jul 17, 2012
Kind
B2
Abstract

The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Claims (8)

1. A composition, comprising:

(a) a compound which disrupts microtubule function selected from taxol, or an analogue or derivative thereof, which is anti-angiogenic by the CAM assay; and

(b) a polymeric carrier selected from the group albumin, gelatin, starch and cellulose;

where the polymeric carrier encapsulates the compound and the composition is in the form of a nanoparticle, the polymeric carrier providing for the sustained release of the compound from the nanoparticle.

2. The composition of claim 1 wherein the carrier comprises albumin.

3. The composition of claim 1 wherein the carrier comprises gelatin.

4. The composition of claim 1 wherein the carrier comprises polysaccharide.

5. The composition of claim 1 , wherein said composition is sterile.

Assignments (10)
RELEASE OF SECURITY INTEREST : RECORDED AT REEL/FRAME - 049288/0184 Recorded Jan 29, 2021
From: CAPITAL ONE, NATIONAL ASSOCIATION
To: ANGIOTECH PHARMACEUTICALS, INC.
Reel/Frame 055171/0634 →
RELEASE OF SECURITY INTEREST : RECORDED AT REEL/FRAME - 049104/0392 Recorded Jan 29, 2021
From: CAPITAL ONE, NATIONAL ASSOCIATION
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 055171/0674 →
SECURITY INTEREST Recorded May 26, 2019
From: ANGIOTECH PHARMACEUTICALS, INC.
To: CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 049288/0184 →
SECURITY INTEREST Recorded May 7, 2019
From: SURGICAL SPECIALTIES CORPORATION LIMITED
To: CAPITAL ONE, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 049104/0392 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE ADDRESS PREVIOUSLY RECORDED ON REEL 042115 FRAME 0140. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Aug 8, 2017
From: ANGIOTECH PHARMACEUTICALS, INC.
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 043332/0360 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 28, 2017
From: ANGIOTECH PHARMACEUTICALS, INC.
To: SURGICAL SPECIALTIES CORPORATION LIMITED
Reel/Frame 042115/0140 →
RELEASE OF SECURITY INTEREST Recorded Apr 15, 2013
From: DEUTSCHE BANK NATIONAL TRUST COMPANY
To: ANGIOTECH PHARMACEUTICALS, INC.; AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.; ANGIOTECH AMERICA, INC.; ANGIOTECH BIOCOATINGS CORP.; ANGIOTECH PHARMACEUTICALS (US), INC.; B.G. SULZLE, INC.; MANAN MEDICAL PRODUCTS, INC.; MEDICAL DEVICE TECHNOLOGIES, INC.; QUILL MEDICAL, INC.; SURGICAL SPECIALTIES CORPORATION; ANGIOTECH INTERNATIONAL HOLDINGS CORP.
Reel/Frame 030218/0820 →
RELEASE OF SECURITY INTEREST Recorded Apr 12, 2013
From: WELLS FARGO CAPITAL FINANCE, LLC
To: ANGIOTECH PHARMACEUTICALS, INC.; AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.; ANGIOTECH AMERICA, INC.; ANGIOTECH BIOCOATINGS CORP.; ANGIOTECH PHARMACEUTICALS (US), INC.; B.G. SULZLE, INC.; MANAN MEDICAL PRODUCTS, INC.; MEDICAL DEVICE TECHNOLOGIES, INC.; QUILL MEDICAL, INC.; SURGICAL SPECIALTIES CORPORATION; ANGIOTECH INTERNATIONAL HOLDINGS CORP.
Reel/Frame 030211/0479 →
PATENT SECURITY AGREEMENT Recorded May 13, 2011
From: ANGIOTECH PHARMACEUTICALS, INC.; AFMEDICA, INC.; AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.; ANGIOTECH AMERICA, INC.; ANGIOTECH BIOCOATINGS CORP.; ANGIOTECH DELAWARE, INC.; ANGIOTECH FLORIDA HOLDINGS, INC.; ANGIOTECH PHARMACEUTICALS (US), INC.; B.G. SULZLE, INC.; MANAN MEDICAL PRODUCTS, INC.; MEDICAL DEVICE TECHNOLOGIES, INC.; NEUCOLL INC.; QUILL MEDICAL, INC.; SURGICAL SPECIALTIES CORPORATION; 0741693 BRITISH COLUMBIA LTD.; ANGIOTECH INTERNATIONAL HOLDINGS, CORP.
To: WELLS FARGO CAPITAL FINANCE, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 026275/0507 →
SECURITY AGREEMENT Recorded May 24, 2010
From: ANGIOTECH PHARMACEUTICALS, INC.; AFMEDICA, INC.; AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.; ANGIOTECH AMERICA, INC.; ANGIOTECH BIOCOATINGS CORP.; ANGIOTECH CAPITAL, LLC; ANGIOTECH PHARMACEUTICALS (US), INC.; B.G. SULZLE, INC.; CRIMSON CARDINAL CAPITAL, LLC; MANAN MEDICAL PRODUCTS, INC.; MEDICAL DEVICE TECHNOLOGIES, INC.; NEUCOLL, INC.; QUILL MEDICAL, INC.; SURGICAL SPECIALTIES CORPORATION; 0741693 B.C. LTD.; 3091796 NOVA SCOTIA COMPANY; ANGIOTECH INTERNATIONAL HOLDINGS, CORP.; ANGIOTECH INVESTMENT PARTNERSHIP
To: WELLS FARGO FOOTHILL, LLC, AS AGENT
Reel/Frame 024431/0804 →
Continuity (8)
Continuation 11151399 · Jun 14, 2005
Continuation 10389262 · Mar 13, 2003
Continuation 09925220 · Aug 8, 2001
Continuation 09294458 · Apr 19, 1999
Continuation 08480260 · Jun 7, 1995
Division 08417160 · Apr 3, 1995
Continuation In Part 08094536 · Jul 19, 1993
Related Publication 20100240742A1 · Sep 23, 2010