IP Library › Granted Patent US 8,343,931
Granted Patent B2
US 8,343,931 · App. 12/716,986 · Granted Jan 1, 2013

Methods of inhibiting photoreceptor apoptosis

Assignee: The Regents of the University of Michigan
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,343,931
App. No.
12/716,986
Granted
Jan 1, 2013
Kind
B2
Abstract

The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis.

Claims (2)

1. A method of increasing photoreceptor survival comprising administering to a subject having retinal detachment a photoreceptor protective composition comprising a photoreceptor protective polypeptide comprising: a) the fragment of MET that is SEQ ID NO:1 (MET12), or (b) a fragment of MET that comprises at least 70% sequence similarity to MET12 wherein said polypeptide inhibits FAS-mediated photoreceptor apoptosis, and wherein increasing photoreceptor survival comprises inhibiting photoreceptor apoptosis.

2. The method of claim 1 , wherein said photoreceptor protective composition is administered to a population of cells.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2010
From: ZACKS, DAVID NOAM
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 024181/0118 →
Continuity (3)
Provisional Application 61157079 · Mar 3, 2009
Provisional Application 61254082 · Oct 22, 2009
Related Publication 20100226878A1 · Sep 9, 2010