IMPLANT OF A BIOCORRODIBLE METALLIC MATERIAL AND ASSOCIATED PRODUCTION METHOD

1 . Method for producing an implant of a biocorrodible metallic material with a nanoparticle-containing silane coating, wherein the method comprises the steps:

(i) Providing a blank for the implant comprising the biocorrodible metallic material, and

(ii) Coating the blank with a homogenous colloidal solution of

A) one or more bis-silanes of the formula (1):

(RO) 3 —Si—X—Si(OR) 3   (1)

wherein R stands for C 1 -C 10 alkyl or C 2 -C 10 acyl; and

X is a substituted or unsubstituted C 1 -C 20 alkanediyl group or a substituted or unsubstituted C 1 -C 20 heteroalkanediyl group with 1 to 5 heteroatoms selected from the group O, N and S; and

B) Silicon dioxide nanoparticles with an average particle diameter in the range of 10 nm to 1 μm in water, ethanol or a mixture of the same, wherein the solution contains 1 to 20% by volume bis-silane and the concentration of the silicon dioxide nanoparticles in the solution is in the range of 1 to 100 ppm.

2 . Method according to claim 1 , in which the biocorrodible metallic material is a biocorrodible alloy selected from the group comprising magnesium, iron, zinc and tungsten.

3 . Method according to claim 2 , in which the biocorrodible metallic material is a magnesium alloy.

4 . Method according to claim 1 , in which R is selected from the group comprising methyl, ethyl, propyl and i-propyl.

5 . Method according to claim 4 , in which the one or more bis-silanes comprise bis-[3-(triethoxysilyl)-propyl]tetrasulfide and/or bis-[3-(trimethoxysilyl-propyl)]amine.

6 . Method according to claim 4 , in which the homogenous colloidal solution contains a mixture of bis-[3-(trimethoxysilylpropyl)]amine and vinyltriacetoxysilane.

7 . Method according to claim 1 , in which step (ii) is repeated n-fold, wherein n=2 to 10 and the homogenous colloidal solution used in each repetition step can be freely selected in terms of its composition.

8 . Implant of a biocorrodible metallic material with a nanoparticle-containing silane coating, wherein the coating comprises

A) one or more bis-silanes of the formula (1):

(RO) 3 —Si—X—Si(OR) 3   (1)

wherein R stands for C 1 -C 10 alkyl or C 2 -C 10 acyl; and

X is a substituted or unsubstituted C 1 -C 20 alkanediyl group or a substituted or unsubstituted C 1 -C 20 heteroalkanediyl group with 1 to 5 heteroatoms selected from the group O, N and S; and

B) Silicon dioxide nanoparticles with an average particle diameter in the range of 10 nm to 1 μm.

9 . Implant according to claim 8 , in which the biocorrodible metallic material is a biocorrodible alloy selected from the group comprising magnesium, iron, zinc and tungsten.

10 . Implant according to claim 9 , in which the biocorrodible metallic material is a magnesium alloy.

11 . Implant according to claim 8 , in which the implant is a stent.

12 . Implant according to claim 8 , in which R is selected from the group comprising methyl, ethyl, propyl and i-propyl.

13 . A method for producing an implant of a biocorrodible metallic material with a nanoparticle-containing silane coating, wherein the method comprises the steps:

providing a blank made from a biocorrodible alloy selected from the group comprising magnesium, iron, zinc and tungsten; and

repeatedly coating the blank with a homogenous colloidal solution containing about 1-20% by volume of one or more of bis-[3-(triethoxysilyl)-propyl]tetrasulfide and bis-[3-(trimethoxysilyl-propyl)]amine, and about 1 to 100 ppm silicon dioxide nanoparticles with an average particle diameter in the range of 10 nm to 1 μm, and containing one or more of water and ethanol.