Spirocyclic heterocyclic derivatives and methods of their use
View Patent ↗Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
1. A method for inhibiting or treating a mood disorder selected from the group consisting of depression and bipolar manic-depression comprising administering to a patient in need thereof an effective amount of a compound of the following formula:
or a pharmaceutically acceptable salt or N-oxide thereof.
2. A method according to claim 1 wherein the mood disorder is depression.
3. A method according to claim 1 wherein the mood disorder is bipolar manic-depression.
4. A method according to claim 1 wherein said compound is in the form of a pharmaceutically acceptable salt.
5. A method according to claim 4 wherein said salt is a hydrochloride salt.
6. A method for inhibiting or treating a mood disorder selected from the group consisting of depression and bipolar manic-depression comprising administering to a patient in need thereof an effective amount of a pharmaceutical composition comprising, in combination with a pharmaceutically acceptable carrier, a compound of the following formula:
or a pharmaceutically acceptable salt or N-oxide thereof.
7. A method according to claim 6 wherein the mood disorder is depression.
8. A method according to claim 6 wherein the mood disorder is bipolar manic-depression.
9. A method according to claim 6 wherein said compound is in the form of a pharmaceutically acceptable salt.
10. A method according to claim 9 wherein said salt is a hydrochloride salt.
11. A method for inhibiting or treating anxiety comprising administering to a patient in need thereof an effective amount of a compound of the following formula:
or a pharmaceutically acceptable salt or N-oxide thereof.
12. A method according to claim 11 wherein said compound is in the form of a pharmaceutically acceptable salt.
13. A method according to claim 12 wherein said salt is a hydrochloride salt.
14. A method for inhibiting or treating anxiety comprising administering to a patient in need thereof an effective amount of a pharmaceutical composition comprising, in combination with a pharmaceutically acceptable carrier, a compound of the following formula:
or a pharmaceutically acceptable salt or N-oxide thereof.
15. A method according to claim 14 wherein said compound is in the form of a pharmaceutically acceptable salt.
16. A method according to claim 15 wherein said salt is a hydrochloride salt.