Inactivation of reverse transcriptases by azido-diarylpyrimidines
View Patent ↗Azido-diarylpyrimidine (azido-DAPY) compounds, and compositions containing such compounds, are provided. In addition, methods of using azido-diarylpyrimidines to inactivate reverse transcriptases, prepare inactivated viruses, and treat or prevent viral infections are also provided.
1. A compound having the formula of formula (I):
wherein R 1 , R 2 , and R 3 are independently N 3 or lower alkyl, with the proviso that at least one of R 1 , R 2 , and R 3 is N 3 .
2. The compound of claim 1 , wherein R 2 and R 3 are CH 3 and R 1 is N 3 .
3. The compound of claim 1 , wherein R 1 and R 3 are CH 3 and R 2 is N 3 .
4. The compound of claim 1 , wherein R 1 and R 2 are CH 3 and R 3 is N 3 .
5. A composition comprising:
a compound having the formula of formula (I):
wherein R 1 , R 2 , and R 3 are independently N 3 or lower alkyl, with the proviso that at least one of R 1 , R 2 , and R 3 is N 3 ; and
a pharmaceutically acceptable carrier.
6. The composition of claim 5 , wherein R 2 and R 3 are CH 3 and R 1 is N 3 .
7. The composition of claim 5 , wherein R 1 and R 3 are CH 3 and R 2 is N 3 .
8. The composition of claim 5 , wherein R 1 and R 2 are CH 3 and R 3 is N 3 .
9. The composition of claim 5 , wherein the composition is formulated as a suppository, pessary, cream, film, foam, gel, paste, or spray.
10. The composition of claim 5 , wherein the composition is formulated in a ring, sponge, or tampon.
11. The composition of claim 5 , wherein the composition comprises 0.1 to 10% by volume of the compound of formula (I).