METHODS OF TREATING DISEASED TISSUE
Treatment protocols for severe psoriasis include administering biologics, stopping all administration of the biologics after the severity of the psoriasis has reduced and has reached an equilibrium, mildness and/or a tolerable state of remission, and administering UV phototherapy. The biologics may include, for example, the biologics found in Amevive®, Enbrel®, Humira®, Raptiva®, and Remicade® and/or alefacept, etanercept, adalimumab, efalizumab, infliximab, and ustekinumab. The UV phototherapy may be repeated, for example daily, weekly, monthly, yearly, to keep the psoriasis in a mild state or in a tolerable state of substantial remission. Parameters for administering UV phototherapy may be determined based on skin tone, Fitzpatrick skin phenotype, the severity of the psoriasis, the area of exposure, and/or the MED.
1 . A method of treating a subject having psoriasis, the method comprising:
administering UV phototherapy to the subject after discontinuing administering a biologic to the subject after improving severity of the psoriasis.
2 . The method of claim 1 , wherein the biologic comprises at least one selected from the group consisting of the biologic found in Amevive®, Enbrel®, Humira®, Raptiva®, and Remicade®.
3 . The method of claim 1 , wherein the biologic comprises at least one selected from the group consisting of alefacept, etanercept, adalimumab, efalizumab, infliximab, and ustekinumab.
4 . The method of claim 1 , wherein discontinuing the biologic is after the psoriasis is moderate.
5 . The method of claim 1 , wherein discontinuing the biologic is after the psoriasis is mild.
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8 . The method of claim 1 , wherein administering the UV phototherapy comprises treating an area of about 2,000 cm 2 .
9 . The method of claim 8 , wherein administering the UV phototherapy comprises treating the area in less than about 3 minutes.
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17 . The method of claim 1 , wherein discontinuing administering the biologic is after the area of psoriasis decreases at least about 50%.
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19 . The method of claim 1 , wherein discontinuing the biologic is after a decrease in severity of the psoriasis to covering less than about 30% of the total body epidermal area of the subject.
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24 . The method of claim 1 , wherein administering the UV phototherapy comprises directing light propagating from a laser to the patient.
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42 . The method of claim 1 , wherein administering the biologic comprises administering two or more biologics.
43 . The method of claim 1 , wherein administering the biologic comprises a plurality of cycles of the biologic.
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53 . The method of claim 1 , further comprising repeating administering the UV phototherapy at least once per day, at least once per week, at least once per month, or at least once per year.
54 . The method of claim 1 , wherein parameters for administering the UV phototherapy are at least partially determined based on the skin tone of the subject, Fitzpatrick skin phenotype of the subject, the severity of the psoriasis, the area of exposure, the MED of the subject, or combinations thereof.
55 . The method of claim 54 , wherein the parameters include at least one of a dosage and a frequency.
56 . The method of claim 54 , wherein a dosage of the UV phototherapy is equal or greater than about 1 MED.
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74 . The method of claim 1 , further comprising continuing administering the UV phototherapy to the subject after the psoriasis becomes mild or in a tolerable state of remission.
75 . A method of treating psoriasis, the method comprising:
identifying a patient on a biologic regimen treating psoriasis;
after the biologic regimen reduces severity of the psoriasis, administering a first UV phototherapy to the subject to further treat the psoriasis to be mild or less; and
administering a second UV phototherapy to the subject to maintain the psoriasis to be mild or less.
76 . A method of treating a subject having severe psoriasis, the method comprising:
administering a first biologic to the subject;
after improving the severe psoriasis, administering a second biologic to the subject;
discontinuing administering the second biologic after further improving the severe psoriasis; and
after discontinuing administering the second biologic, instructing the subject to undergo UV phototherapy.
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85 . The method of claim 76 , further comprising, prior to administering the second biologic, discontinuing administering the first biologic.
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