3,6-substituted imidazol[1,2-b]pyridazine analogs for treating allergic and inflammatory diseases
View Patent ↗Methods for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition characterized by administering a composition which contains a therapeutically effective amount of a 3,6-substituted imidazol[1,2-b]pyridazine compound.
1. A method for treating an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition in a patient which comprises administering to the patient a composition comprising a therapeutically effective amount of a compound of the formula:
wherein:
A=aryl or heteroaryl optionally substituted by F, Cl, Br, C 1 -C 6 alkyl, OR 2 , or OCF 3 ;
R 1 =H, C 1 -C 6 alkyl, heterocyclyl, or (CH 2 ) n —X;
n=1-4;
X=aryl, heteroaryl, OR 5 or NR 3 R 4 ; and
R 2 , R 3 , R 4 , R 5 independently=H or C 1 -C 6 alkyl;
provided that the allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition is selected from the group consisting of nasal allergic disorders; rhinitis; and sinusitis.
2. The method of claim 1 wherein the allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition is an allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition of the nose.
3. The method of claim 2 wherein the composition is topically administered to the patient.
4. The method of claim 3 wherein the therapeutically effective amount of the compound is 0.00001-5% (w/v).
5. The method of claim 4 wherein the therapeutically effective amount of the compound is 0.0001-0.5% (w/v).
6. The method of claim 2 wherein the composition is topically administered to the nose of the patient.
7. The method of claim 6 wherein the allergic or inflammatory disease or other Syk-mediated disease or Syk-mediated condition is a nasal allergic disorder.
8. The method of claim 7 wherein the nasal allergic disorder is selected from the group consisting of allergic rhinitis and sinusitis.