Bioactive substance in a barbed suture
Barbed surgical sutures are provided which include an elongated body and a plurality of barbs extending therefrom. A bioactive agent is disposed within barb angles formed between the barbs and the elongated body. The barbs may be made from a shape memory polymer having a permanent shape which may be deformed to a temporary shape, such that barbs of the suture extend at different barb angles in the different shape configurations. The barb angles of the permanent shape may be greater than the barb angles of the temporary shape, thereby exposing and/or releasing a bioactive agent after placement in tissue.
1. A method of releasing a bioactive agent from a suture comprising:
providing a suture in a temporary shape, the suture comprising:
an elongated body;
a plurality of barbs extending from the elongated body and forming a barb angle between an inner surface of the barbs and an outer surface of the elongated body, at least a portion of the plurality of barbs being made from a shape memory polymer having a temporary shape in which the barbs are compressed against the elongated body; and
an effective amount of a bioactive agent disposed within the barb angles formed between the inner surface of the barbs and the outer surface of the elongated body; and
placing the suture into tissue such that the barbs recover from the temporary shape into a permanent shape in which the barbs extend outwardly and away from the elongated body, thereby releasing the bioactive agent from the barb angles and into the tissue.
2. The method of claim 1 , wherein providing the suture includes providing the suture in a temporary shape such that the plurality of barbs extend substantially parallel with a longitudinal axis of the suture.
3. The method of claim 1 , wherein releasing the bioactive agent into the tissue includes releasing the bioactive agent from the barb angles upon transitioning of the plurality of barbs from the temporary shape to the permanent shape.
4. The method of claim 1 , wherein providing the suture includes providing a first portion of the plurality of barbs with first recovery temperature and a second portion of the plurality of barbs with a second recovery temperature, thereby providing controlled and sustained release of the bioactive agent upon placement into tissue.
5. The method of claim 4 , wherein placing the suture into tissue further comprises recovering the permanent shape of the first portion of the plurality of barbs upon exposure to body temperature.
6. The method of claim 5 , further comprising applying an electric stimuli to recover the permanent shape of the second portion of the plurality of barbs.