Irradiated implantable bone material
View Patent ↗A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.
1. A method for producing demineralized bone compositions having uniform osteoinductivity, the method comprising:
(a) obtaining bone portions from a human donor subject;
(b) demineralizing the bone portions to produce demineralized bone portions having no osteoinductivity; and
(c) irradiating the demineralized bone portions at a temperature less than about 0° C. and at a dose of radiation sufficient to increase osteoinductivity to an Osteoinduction Grading Score of at least 2.
2. A method according to claim 1 , wherein the bone portions are obtained from a plurality of donor subjects.
3. A method according to claim 1 , wherein the demineralized bone portions comprise bone powder.
4. A method according to claim 1 , wherein irradiating comprises administering a sterilizing dose of radiation.