Parasiticidal formulation
View Patent ↗The present invention provides a parasiticidal formulation comprising: Fipronil, or a veterinarily acceptable derivative thereof; at least one C 1 -C 6 alcohol co-solvent, wherein the total amount of C 1 -C 6 alcohol is up to 8% by weight of the formulation; at least one organic solvent which is not the C 1 -C 6 alcohol co-solvent; and at least one crystallization inhibitor, wherein the total amount of crystallization inhibitor is from 2 to 20% by weight of the formulation. The formulations of the invention have higher flash points than known parasiticidal formulations comprising Fipronil and therefore provide safer formulations for use in the home, storage, manufacture and distribution.
1. A parasiticidal formulation comprising:
from about 8% to about 12% by weight Fipronil, or a veterinarily acceptable derivative thereof;
at least one C 1 -C 6 alcohol co-solvent, wherein the total amount of the C 1 -C 6 alcohol is no more than about 5% by weight of the formulation; and
at least one organic solvent which is not the C 1 -C 6 alcohol co-solvent.
2. The formulation of claim 1 , further comprising at least one crystallization inhibitor, wherein the total amount of the crystallization inhibitor is from 2 to 20% by weight of the formulation.
3. The formulation of claim 1 , wherein the Fipronil or a veterinarily acceptable derivative thereof, is Fipronil.
4. The formulation of claim 1 , which further comprises S-Methoprene.
5. The formulation of claim 4 , wherein the amount of S-Methoprene is from about 5% to about 25% by weight of the formulation.
6. The formulation of claim 2 , wherein the at least one crystallization inhibitor is polyethylene glycol, polyethylene glycol hydrogenated castor oil, or combinations thereof.
7. The formulation of claim 6 , wherein the at least one crystallization inhibitor is a combination of polyethylene glycol and polyethylene glycol hydrogenated castor oil.
8. The formulation of claim 7 , wherein the amount of polyethylene glycol is about 5% by weight of the formulation and the amount of polyethylene glycol hydrogenated castor oil is about 5% by weight of the formulation.
9. The formulation of claim 1 , wherein the at least one organic solvent which is not the C 1 -C 6 alcohol co-solvent is diethylene glycol monoethyl ether, ethylene glycol monoethyl ether, dipropylene glycol n-butyl ether, dipropylene glycol monomethyl ether, or combinations thereof.
10. The formulation of claim 9 , wherein the at least one organic solvent which is not the C1-C6 alcohol co-solvent is diethylene glycol monoethyl ether.
11. A method for controlling parasites on mammals in need thereof, said method comprising treating the mammal by application to the skin of parasiticidally effective dose of the parasiticidal formulation of claim 1 .
12. The method of claim 11 , wherein the mammal is treated by local point application to the skin of a spot-on formulation comprising the parasiticidal formulation of claim 1 .
13. The method of claim 11 , wherein the parasites are one or more ectoparasites.
14. A parasiticidal formulation consisting of:
about 9.7 wt % Fipronil;
ethanol in an amount no greater than about 5.0 wt %;
about 0.02 wt % butylated hydroxylanisole;
about 0.01 wt % butylated hydroxyltoluene;
about 5.0 wt % polyethylene glycol 1000;
about 5.0 wt % polyethylene glycol 60 hydrogenated castor oil;
balance diethylene glycol monoethyl ether.
15. A parasiticidal formulation consisting of:
about 9.8 wt % Fipronil;
about 11.8 wt % S-Methoprene;
ethanol in an amount no greater than about 5.0 wt %;
about 0.02 wt % butylated hydroxylanisole;
about 0.01 wt % butylated hydroxyltoluene;
about 5.0 wt % polyethylene glycol 1000;
about 5.0 wt % polyethylene glycol 60 hydrogenated castor oil;
balance diethylene glycol monoethyl ether.
16. A parasiticidal formulation consisting of:
about 9.8 wt % Fipronil;
about 8.8 wt % S-Methoprene;
ethanol in an amount no greater than about 5.0 wt %;
about 0.02 wt % butylated hydroxylanisole;
about 0.01 wt % butylated hydroxyltoluene;
about 5.0 wt % polyethylene glycol 1000;
about 5.0 wt % polyethylene glycol 60 hydrogenated castor oil;
balance diethylene glycol monoethyl ether.
17. The method of claim 11 , wherein the mammals are one or more of cats and dogs.
18. The method of claim 13 , wherein the one or more ectoparasites include at least one of fleas and ticks.