Medical device with adherent coating, and method for preparing same
View Patent ↗A medical device such as a wire guide has a lubricious and/or therapeutic coating adhered to an etched, carbonaceous polymeric surface, for example a sodium-etched polymer surface. A method for preparing a lubricious and/or therapeutic coating on a medical device includes etching a polymeric portion of the device to create a carbonaceous surface and applying a lubricious and/or therapeutic coating on the etched surface.
1. A method for applying a lubricious and/or therapeutic coating to a medical device, comprising applying a lubricous and/or therapeutic coating to a sodium etched carbonaceous surface of a polymeric portion of the device, wherein said lubricious and/or therapeutic coating comprises an antibiotic or anti-thrombogenic agent.
2. The method of claim 1 , wherein the polymer is a fluoropolymer.
3. The method of claim 2 , wherein the fluoropolymer is polytetrafluoroethylene.
4. The method of claim 1 , wherein the medical device is a wire guide, catheter, or stent.
5. The method of claim 4 , wherein the medical device is a wire guide.
6. The method of claim 1 , which comprises applying said lubricious coating, wherein said lubricious coating comprises one or more polymers non-covalently adhered to the polymer surface.
7. The method of claim 6 , wherein said lubricous coating comprises polyvinylpyrrolidone or a copolymer thereof.
8. A method for manufacturing a medical wire guide, comprising:
providing an elongate wire;
applying a fluoropolymer coating on the elongate wire;
etching the fluoropolymer coating with sodium metal to faun an etched fluoropolymer surface; and
applying a lubricious coating to the etched fluoropolymer surface so as to provide to the device an overlying lubricious layer that provides lubricity to the device as the device traverses a body passageway;
wherein the fluoropolymer is polytetrafluoroethylene; and
wherein said lubricious coating comprises one or more polymers non-covalently adhered to the fluoropolymer surface.
9. The method of claim 8 , wherein said lubricous coating comprises polyvinylpyrrolidone or a copolymer thereof.
10. A method for applying a lubricious and/or therapeutic coating to a medical device, comprising applying a lubricous and/or therapeutic coating to an etched carbonaceous surface of a polymeric portion of the device so as to provide to the device an overlying lubricious and/or therapeutic layer that provides lubricity to the device as the device traverses a body passageway and/or that incorporates a therapeutic agent for release within the body;
wherein the etched carbonaceous surface has been sodium etched; and
wherein said lubricious and/or therapeutic coating comprises an antibiotic or anti-thrombogenic agent.
11. The method of claim 10 , wherein the polymeric portion comprises a fluoropolymer.
12. The method of claim 11 , wherein the fluoropolymer is polytetrafluoroethylene.
13. The method of claim 10 , wherein the medical device is a wire guide, catheter, or stent.
14. The method of claim 13 , wherein the medical device is a wire guide.
15. The method of claim 10 , wherein said lubricious and/or therapeutic coating comprises one or more film-forming polymers.
16. A method for manufacturing a medical wire guide, comprising:
providing an elongate wire;
applying a polytetrafluoroethylene coating on the elongate wire;
etching the polytetrafluoroethylene coating with sodium metal to form an etched polytetrafluoroethylene surface; and
applying a lubricious coating to the etched polytetrafluoroethylene surface, wherein the lubricous coating comprises one or more polymers non-covalently adhered to the polytetrafluoroethylene surface.
17. The method of claim 16 , wherein said lubricous coating comprises polyvinylpyrrolidone or a copolymer thereof.