IP Library › Granted Patent US 8,362,209
Granted Patent B2
US 8,362,209 · App. 12/733,277 · Granted Jan 29, 2013

Telomerase reverse transcriptase variant

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Quick Facts
Patent No.
US 8,362,209
App. No.
12/733,277
Granted
Jan 29, 2013
Kind
B2
Abstract

The present invention relates to nucleic and amino acid sequences of a novel variant of the telomerase reverse transcriptase. More particularly, the present invention is directed to a novel variant of human telomerase reverse transcriptase, which displays properties distinct from those of wildtype telomerase reverse transcriptase, and methods of use thereof.

Claims (4)

1. An isolated polypeptide comprising SEQ ID NO: 2, wherein said isolated polypeptide effects a delay in cell cycle progression and increases sensitivity of cells to mitochondrial DNA damage or apoptosis induced by an oxidative stressor.

2. An isolated antibody immunologically specific for the isolated polypeptide comprising SEQ ID NO:2.

3. The antibody of claim 2 , wherein said antibody is a polyclonal antibody.

4. The antibody of claim 2 , wherein said antibody is a monoclonal antibody.

Assignments (2)
NUNC PRO TUNC ASSIGNMENT Recorded Sep 6, 2013
From: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
To: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Reel/Frame 031152/0452 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2010
From: SANTOS, JANINE H.
To: UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
Reel/Frame 024534/0501 →