IP Library › Granted Patent US 9,018,157
Granted Patent B2
US 9,018,157 · App. 12/734,596 · Granted Apr 28, 2015

Prevention and treatment of inflammation and organ injury after ischemia/reperfusion using MFG-E8

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Quick Facts
Patent No.
US 9,018,157
App. No.
12/734,596
Granted
Apr 28, 2015
Kind
B2
Abstract

Provided are methods for preventing and treating inflammation and organ injury after ischemia/reperfusion, and methods for treating lung injury, comprising administering a milk fat globule epidermal growth factor-factor VIII (MFG-E8) to a subject. Also provided are pharmaceutical compositions comprising MFG-E8 in dosage form for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, and methods of preparing a pharmaceutical composition for preventing and treating inflammation and organ injury after ischemia/reperfusion, and for treating lung injury, comprising formulating MFG-E8 in a pharmaceutical composition.

Claims (16)

1. A method of attenuating organ injury after ischemia/reperfusion in a subject comprising administering to the subject a milk fat globule epidermal growth factor-factor VIII (MFG-E8) having a sequence at least 99% identical to SEQ ID NO:1 or SEQ ID NO:2 in an amount effective to attenuate organ injury after ischemia/reperfusion.

2. The method of claim 1 , wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:1.

3. The method of claim 1 , wherein the MFG-E8 has an amino acid sequence identical to SEQ ID NO:1.

4. The method of claim 1 , wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:2.

5. The method of claim 1 , wherein the MFG-E8 has an amino acid sequence identical to SEQ ID NO:2.

6. The method of claim 1 , wherein the MFG-E8 is recombinant MFG-E8.

7. The method of claim 1 , wherein the organ is one or more of gastrointestinal tract, liver, lung, kidney, heart, brain, spinal cord or crushed limb.

8. The method of claim 1 , where the organ injury is acute lung injury.

9. The method of claim 1 , wherein the ischemia/reperfusion is one or more of gastrointestinal tract, liver, lung, kidney, heart, brain, spinal cord or crushed limb ischemia/reperfusion.

10. The method of claim 1 , wherein the ischemia/reperfusion is intestinal ischemia/reperfusion.

11. A method of treating lung injury after ischemia/reperfusion in a subject comprising administering to the subject a milk fat globule epidermal growth factor-factor VIII (MFG-E8) having a sequence at least 99% identical to SEQ ID NO:1 or SEQ ID NO:2 in an amount effective to treat lung injury after ischemia/reperfusion.

12. The method of claim 11 , wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:1.

13. The method of claim 11 , wherein the MFG-E8 has an amino acid sequence identical to SEQ ID NO:1.

14. The method of claim 11 , wherein the MFG-E8 has an amino acid sequence at least 99% identical to SEQ ID NO:2.

15. The method of claim 11 , wherein the MFG-E8 has an amino acid sequence identical to SEQ ID NO:2.

16. The method of claim 11 , wherein the MFG-E8 is recombinant MFG-E8.

Assignments (1)
CHANGE OF NAME Recorded Aug 21, 2019
From: THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
To: THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
Reel/Frame 050114/0931 →