Process for production of N-carbamoyl-tert-leucine
View Patent ↗The present invention relates to a process for producing an N-carbamoyl-tert-leucine, characterized in mixing tert-leucine with an isocyanic acid compound while a pH of the mixture is kept at not less than 8.0 and not more than 13.5, wherein an amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to an amount of the tert-leucine. According to the present invention, it becomes possible to easily produce an N-carbamoyl-tert-leucine with high efficiency, while the generation of by-products such as a dipeptide-like compound and a urea compound is prevented.
1. A process for production of an N-carbamoyl-tert-leucine represented by the general formula (2):
wherein, R 1 is a hydrogen atom, an optionally substituted alkyl group having 1 to 10 carbon atoms, or an optionally substituted aryl group having 6 to 12 carbon atoms,
comprising a step of mixing tert-leucine with an isocyanic acid compound represented by the general formula (1):
R 1 —N═C═O (1)
wherein, R 1 is the same as described above,
while a pH of the mixture is kept at a range of not less than 8.0 and less than 13.0,
wherein the amount of the isocyanic acid compound is not less than 0.9 times by mole and not more than 1.1 times by mole relative to the amount of the tert-leucine.
2. The production process according to claim 1 , wherein R 1 is an alkyl group having 2 to 6 carbon atoms or an aryl group having 6 carbon atoms.
3. The production process according to claim 1 , wherein the N-carbamoyl-tert-leucine represented by the general formula (2) is an optically-active substance.
4. The production process according to claim 2 , wherein the N-carbamoyl-tert-leucine represented by the general formula (2) is an optically-active substance.
5. The production process according to claim 1 , wherein the total amount of a single solvent or a mixed solvent in the reaction mixture is not less than 2 times by weight and not more than 20 times by weight relative to the amount of the tert-leucine.