DRUG RELEASE COATINGS ON CALCUIM PHOSPHATE AND USES THEREOF
The invention provides implantable drug releasing materials comprising a calcium phosphate composition, a biodegradable polymer adsorbed onto the calcium phosphate composition, wherein the polymer comprises acidic amino acid residues, and a drug adsorbed onto or reacted with the polymer. The invention is further directed to dental and bone implants and implantable medical devices comprising the implantable drug releasing material, methods for preparing the implantable drug releasing material, and methods for delivering the implantable drug releasing material to bone or teeth.
1 . An implantable drug releasing material comprising:
a) a calcium phosphate composition;
b) a biodegradable polymer adsorbed onto the calcium phosphate composition, wherein the polymer comprises acidic amino acid residues; and
c) a drug adsorbed onto or chemically bound to the polymer.
2 . The implantable drug releasing material of claim 1 , wherein the calcium phosphate composition comprises hydroxyapatite or tricalcium phosphate.
3 . The implantable drug releasing material of claim 1 , wherein the polymer is a polypeptide polymer.
4 . The implantable drug releasing material of claim 1 , wherein the polymer comprises residues of aspartic acid and/or glutamic acid.
5 . The implantable drug releasing material of claim 1 , wherein the polymer comprises phosphoserine.
6 . The implantable drug releasing material of claim 1 , wherein the polymer is a poly(glutamic acid) polymer or a poly(aspartic acid) polymer.
7 . The implantable drug releasing material of claim 1 , wherein the polymer comprises branched polypeptides.
8 . The implantable drug releasing material of claim 1 , wherein the polymer is a block co-polymer.
9 . The implantable drug releasing material of claim 8 , wherein one block comprises peptide sequences with acidic residues and another block is optimized to bind a drug.
10 . The implantable drug releasing material of claim 1 , wherein the polymer is bound to the calcium phosphate composition by ionic interaction.
11 . The implantable drug releasing material of claim 1 , wherein the polymer is formed as a monolayer.
12 . The implantable drug releasing material of claim 1 , wherein the drug is an antibiotic, a chemotherapeutic agent, an analgesic, a growth factor, an anesthetic, an anti-inflammatory drug or a cell signaling compound.
13 . The implantable drug releasing material of claim 1 , wherein the drug is an antibiotic.
14 . The implantable drug releasing material of claim 13 , wherein the antibiotic is an aminoglycoside.
15 . The implantable drug releasing material of claim 13 , wherein the antibiotic is gentamicin, tobramycin or vancomycin.
16 . The implantable drug releasing material of claim 1 , wherein the drug is a chemotherapeutic agent.
17 . The implantable drug releasing material of any of claim 16 , wherein the chemotherapeutic agent is cisplatin.
18 . The implantable drug releasing material of claim 1 , wherein the ratio of the number of monomers in the polymer to the number of drug molecules is about 10:1.
19 . The implantable drug releasing material of claim 1 , wherein the drug is bound to the polymer by ionic interaction.
20 . The implantable drug releasing material of claim 1 , wherein the drug is bound to the polymer by a coordinate bond.
21 . A dental implant or a bone implant comprising the implantable drug releasing material of claim 1 .
22 . (canceled)
23 . A method of preparing an implantable drug releasing material comprising:
a) adsorbing a biodegradable polymer to a calcium phosphate composition, wherein the polymer comprises acidic amino acid residues; and
b) adsorbing or chemically binding a drug onto the polymer.
24 - 47 . (canceled)
48 . A method of delivering a drug to a bone or to a tooth comprising applying the implantable drug releasing material of claim 1 to the bone or tooth.