Device for indicator dilution measurements
View Patent ↗The invention relates to indicator dilution measurements of a central volume (V 1 ) with a first site of injection (S 1 ) upstream of the central volume (V 1 ) a second site of detection (S 2 ) of the diluted indicator downstream of the central volume (V 1 ), wherein a first additional volume (V 2 ) is defined between the first site (S 1 ) and the central volume (V 1 ) and a first additional branch (B 2 ) is defined between the first site (S 1 ) and the central volume (V 1 ) and wherein a second additional volume (V 3 ) is defined between the central volume (V 1 ) and the second site (S 2 ) and a second additional branch (B 3 ) is defined between the central volume (V 1 ) and the second site (S 2 ) wherein a result of central volumetric parameters are corrected for the first and second additional volumes (V 2 , V 3 ) and/or for the first and second additional branches (B 2 , B 3 ).
1. A method for correcting a dilution-based determination of an internal volume of a heart based on flow of a diluted indicator between an injection site upstream of the heart and a detection site downstream of the heart, the method comprising:
injecting indicator at the injection site;
diluting the injected indicator in blood flowing through the heart between the injection site and the detection site;
detecting diluted indicator at the detection site; and
operating a processor configured to carry out the steps of:
calculating the internal volume of the heart based on a detection of the diluted indicator at the detection site;
estimating an additional volume through which the injected indicator flows, the estimated additional volume being estimated as substantially an entire internal volume of a blood vessel through which the injected indicator flows between the injection site and the entrance to the right atrium of the heart; and
calculating and applying a correction to calculation of the internal volume of the heart based on the estimated additional volume.
2. A method for correcting a dilution-based determination of an internal volume of a heart based on flow of a diluted indicator between an injection site upstream of the heart and a detection site downstream of the heart, the method comprising:
injecting indicator at the injection site;
diluting the injected indicator in blood flowing through the heart between the injection site and the detection site;
detecting diluted indicator at the detection site; and
operating a processor configured to carry out the steps of:
calculating the internal volume of the heart based on a detection of the diluted indicator at the detection site;
estimating an additional volume through which the injected indicator flows, the estimated additional volume being estimated as substantially an entire internal volume of a blood vessel through which the injected indicator flows between the aortic valve and the detection site; and
calculating and applying a correction to the calculation of the internal volume of the heart based the estimated additional volume.
3. A method for correcting a dilution-based determination of an internal volume of a heart based on flow of a diluted indicator between an injection site upstream of the heart and a detection site downstream of the heart, the method comprising:
injecting indicator at the injection site;
diluting the injected indicator in blood flowing through the heart between the injection site and the detection site;
detecting diluted indicator at the detection site; and
operating a processor configured to carry out the steps of:
calculating the internal volume of the heart based on a detection of the diluted indicator at the detection site; and
calculating and applying a correction to the calculation of the internal volume of the heart based on an estimated flow of blood in a branch through which no indicator flows but through which blood flows upstream of the heart before entering the heart.
4. A method for correcting a dilution-based determination of an internal volume of a heart based on flow of a diluted indicator between an injection site upstream of the heart and a detection site downstream of the heart, the method comprising:
injecting indicator at the injection site;
diluting the injected indicator in blood flowing through the heart between the injection site and the detection site;
detecting diluted indicator at the detection site; and
operating a processor configured to carry out the steps of:
calculating the internal volume of the heart based on the detection of the diluted indicator at the detection site; and
calculating and applying a correction to the calculation of the internal volume of the heart based on an estimated flow of blood in a branch downstream of the heart and through which indicator flows but not past the detection site.