COMBINATION THERAPY
The present invention provides inhalation compositions comprising montelukast acid and a second active agent selected from a PDE4 inhibitor and an inhaled corticosteroid. Also provided is a method for the treatment of respiratory disorders such as asthma using such compositions.
1 . A medicinal preparation comprising montelukast acid and a second active agent selected from a PDE-4 inhibitor and an inhaled corticosteroid as a combined preparation for simultaneous, sequential or separate administration by inhalation.
2 . A preparation of claim 1 wherein said second active agent is Compound X having the formula:
3 . A preparation of claim 1 wherein said second active agent is mometasone furoate.
4 . A preparation of claim 1 adapted for use in a dry powder inhaler or a metered dose inhaler.
5 . A preparation of claim 2 adapted for use in a dry powder inhaler or a metered dose inhaler.
6 . A preparation of claim 3 adapted for use in a dry powder inhaler or a metered dose inhaler.
7 .- 10 . (canceled)
11 . A method for the treatment of respiratory disorder comprising the simultaneous, sequential or separate administration by inhalation to a patient in need thereof a therapeutically effective amount of montelukast acid and a therapeutically effective amount of a second active agent selected from a PDE-4 inhibitor and an inhaled corticosteroid.
12 . A method of claim 11 wherein said second active agent is Compound X.
13 . A method of claim 11 wherein said second active agent is mometasone furoate.
14 . A method of claim 11 wherein said second active agent is ciclesonide.
15 . A method of claim 11 wherein said respiratory disorder is asthma.
16 . A dry powder inhaler which contains the medicinal preparation of claim 1 .
17 . A metered dose inhaler which contains the medicinal preparation of claim 1 .