Oligomer-nitroimidazole anti-infective conjugates
View Patent ↗The invention provides (among other things) small molecule drugs that are chemically modified by covalent attachment of a water soluble oligomer.
1. A compound of the structure:
wherein:
(a) is 2 or 3;
each instance of R 1 is hydrogen;
each instance of R 2 is hydrogen;
R 3 is selected from the group consisting of hydrogen, methyl and ethyl; and
(n) is an integer of from 3 to 7 inclusive.
2. The compound of claim 1 , wherein (a) is 2 and R 3 is selected from the group consisting of methyl and ethyl.
3. The compound of claim 1 , wherein (a) is 2 and R 3 methyl.
4. A composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.
5. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.