Stabilization of oily suspensions comprising hydrophobic silicas
View Patent ↗The invention relates to a stabilization of fluid oil-based suspensions comprising a hydrophobic silica, and medicaments based on such suspensions.
1. A method for stabilizing a fluid oil-based suspension comprising an active pharmaceutical ingredient and a hydrophobic silica against sedimentation, the method comprising contacting the hydrophobic silica with an amphiphilic substance comprising a nonionic polyoxyethylated compound in the fluid oil-based suspension, wherein the polyoxyethylated compound is selected from the group consisting of poloxamers, polyoxyethylene fatty acid glycerides, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acids, and polyoxyethylene fatty alcohols, and wherein the stabilized fluid oil-based suspension, following contact with the amphiphilic substance, comprises the amphiphilic substance in a proportion of 0.001-0.15% by weight.
2. The method according to claim 1 , wherein the active ingredient is a fluoroquinolone.
3. The method according to claim 2 , wherein the fluoroquinolone is enrofloxacin.
4. The method according to claim 2 , wherein the fluoroquinolone is pradofloxacin.
5. The method according to claim 2 , wherein the fluoroquinolone is marbofloxacin.
6. The method according to claim 2 , further comprising an antimycotic.
7. The method according to claim 6 , wherein the antimycotic is selected from the group consisting of clotrimazole, miconazole and bifonazole.
8. The method according to claim 2 , further comprising a corticoid.
9. The method according to claim 8 , wherein the corticoid is selected from the group consisting of dexamethasone, betamethasone and triamcinolone.
10. The method according to claim 1 , wherein the active ingredient is a triazine.
11. The method according to claim 1 , wherein the fluid oil-based suspension comprises the hydrophobic silica in a proportion of 0.15-4.0% by weight.
12. The method according to claim 1 , wherein the stabilized fluid oil-based suspension, following contact with the amphiphilic substance, comprises the amphiphilic substance in a proportion of 0.01-0.07% by weight.
13. The method according to claim 1 , wherein the stabilized fluid oil-based suspension, following contact with the amphiphilic substance, comprises the amphiphilic substance in a proportion of 0.005-0.09% by weight.
14. The method according to claim 1 , wherein the stabilized fluid oil-based suspension, following contact with the amphiphilic substance, comprises the amphiphilic substance in a proportion of 0.005-0.08% by weight.