Medicinal inhalation devices and components thereof

1. A method of making a medicinal inhalation device or a component of a medicinal inhalation device, said method comprising a step of: applying to at least a portion of a surface of the device or the component, respectively, a composition comprising a monofunctional polyfluoropolyether silane and a non-fluorinated cross-linking agent.

2. A method according to claim 1 , wherein the polyfluoropolyether segment of the polyfluoropolyether silane is not linked to the functional silane group(s) via a functionality that includes nitrogen-silicon bond or a sulfur-silicon bond.

3. A method according to claim 1 , wherein the polyfluoropolyether segment of the polyfluoropolyether silane is linked to the functional silane group(s) via a functionality that includes a carbon-silicon bond.

4. A method according to claim 3 , wherein the polyfluoropolyether segment of the polyfluoropolyether silane is linked to the functional silane group(s) via a —C(R) 2 —Si functionality where R is independently hydrogen or a C 1-4 alkyl group.

5. A method according to claim 4 , wherein the polyfluoropolyether segment of the polyfluoropolyether silane is linked to the functional silane group(s) via a —(CR 2 ) k —C(R) 2 —Si functionality where k is at least 2 and where R is independently hydrogen or a C 1-4 alkyl group.

6. A method according to claim 1 , wherein the polyfluoropolyether segment of the polyfluoropolyether is a perfluorinated polyfluoropolyether segment.

7. A method according to claim 6 , wherein in the repeating units of the perfluorinated polyfluoropolyether segment the number of carbon atoms in sequence is at most 6.

8. A method according to claim 1 , wherein the weight average molecular weight of the polyfluoropolyether segment is about 1000 or higher.

9. A method according to claim 1 or 8 , wherein the weight average molecular weight of the polyfluoropolyether segment is about 6000 or less, in particular about 4000 or less.

10. A method according to claim 1 , wherein the cross-linking agent comprises one or more non-fluorinated compounds, each compound being independently selected from the group consisting of a compound having at least two hydrolysable groups and a compound having at least one reactive functional group and at least one hydrolysable group.

11. A method according to claim 1 , wherein the composition is applied to said surface, such that polyfluoropolyether-containing coating provided on said surface has a thickness of at most about 300 nm.

12. A method according to claim 1 or 11 , wherein the composition is applied to said surface, such that polyfluoropolyether-containing coating provided on said surface has a thickness of at least about 20 nm.

13. A medicinal inhalation device or a component of a medicinal inhalation device made according to claim 1 .

14. A medicinal inhalation device or a component of a medicinal inhalation device comprising a polyfluoropolyether-containing coating bonded to at least a portion of a surface of the device or the component, respectively, said polyfluorpolyether-containing coating comprising a plurality of monofunctional polyfluoropolyether-silane entities cross-linked through non-fluorinated cross-linking entities and said polyfluorpolyether-containing coating sharing at least one covalent bond with said surface.

15. A device or a component according to claim 13 or 14 , where said medicinal inhalation device is a metered dose inhaler or a dry powder inhaler.