ANTIHELMINTIC PASTE

1 - 16 . (canceled)

17 . An anthelmintic paste in form of an aqueous suspension, comprising

a veterinarily effective amount of praziquantel;

a macrocyclic lactone selected from avermectins, milbemycins and derivatives thereof;

a cyclodextrin;

a thickener; and

water.

18 . The paste according to claim 17 , wherein the macrocyclic lactone is of formula

wherein X is —C(H)(OH)—; —C(O)—; or —C(═N—OH)—; Y is —C(H 2 )—; ═C(H)—; —C(H)(OH)—; or —C(═N—OCH 3 )—; R 1 is hydrogen or one of radicals

R 4 is hydroxyl, —NH—CH 3 or —NH—OCH 3 ; and R 2 is hydrogen, —CH 3 , —C 2 H 5 , —CH(CH 3 ) 2 , —CH(CH 3 )—C 2 H 5 , —C(CH 3 )═CH—CH(CH 3 ) 2 or cyclohexyl; and if the bond between atoms 22 and 23 represents a double bond the carbon atom in 23-position is unsubstituted so that Y is ═C(H)—, or if the bond between atoms 22 and 23 is a single bond the carbon atom in 23-position is unsubstituted or substituted by hydroxy or by the group ═N—O—CH 3 so that Y is —C(H 2 )—; —C(H)(OH)—; or —C(═N—OCH 3 )—; in free form or in the form of a physiologically acceptable salt.

19 . A paste according to claim 17 , wherein the macrocyclic lactone is ivermectin or milbemycin oxime.

20 . A paste according to claim 17 , comprising

0.5 to 20% by weight of praziquantel;

0.1 to 8% by weight of a macrocyclic lactone;

0.5 to 40% by weight of a cyclodextrin;

0.1 to 10% by weight of a thickener; and

ad 100% by weight water.

21 . A paste according to claim 17 , comprising

2.0 to 7.5% by weight of praziquantel;

1.0 to 2.5% by weight of a macrocyclic lactone,

2.0 to 7.5% by weight of a cyclodextrin;

1.0 to 5.0% by weight of a thickener; and

ad 100% by weight water.

22 . A paste according to claim 21 , wherein the macrocyclic lactone is milbemycin oxime.

23 . A paste according to claim 17 , comprising one or more additional components selected from the group consisting of humectants, preservatives, pH-adjusting agents, colors and flavors.

24 . A paste according to claim 17 , comprising a water content of ≧50% by weight, based on the entire formulation.

25 . A paste according to claim 24 , comprising a water content of ≧60% by weight, based on the entire formulation.

26 . A paste according to claim 17 , which is devoid of oils, polyglycols, glycol ethers, glycerol formal and surfactants.

27 . A paste according to claim 18 , consisting of

1.0 to 10% by weight of praziquantel;

0.5 to 5% by weight of milbemycin oxime;

1.0 to 20% by weight of a cyclodextrin;

0.5 to 7.5% by weight of thickeners;

1.0 to 10% by weight of humectants;

0.5 to 5% by weight of preservatives;

2.5 to 20% by weight of flavors;

0 to 5.0% by weight colors; and

ad 100% by weightwater and acid.

28 . A paste according to claim 17 , wherein the paste has a specific gravity from 1.05 to 1.15.

29 . A paste according to claim 17 , wherein the paste is thixotropic.

30 . Process for the manufacture of an anthelmintic paste according to claim 17 , comprising

(i) providing the water and optionally further ingredients which are water-soluble,

(ii) adding the cyclodextrin and disperse and/or partly dissolve it in the water,

(iii) adding the praziquantel and disperse it in the water/cyclodextrin mixture,

(iv) dispersing the macrocyclic lactone, optional further ingredients and a thickener consecutively, and

(v) stirring the dispersion until a homogeneous paste is formed.

31 . A method of controlling endoparasites in a warm-blooded animal, which comprises administering an anthelmintic paste according to claim 17 orally to the warm-blooded animal.

32 . A method according to claim 31 , wherein the warm-blooded animal is a dog or cat.