Mechanism-based small-molecule parasite inhibitors
View Patent ↗Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.
1. A method for treating an Apicomplexan parasite infection in a patient, said method comprising administering to a patient in need thereof an effective amount of a compound of Formula IV:
or a pharmaceutically acceptable salt thereof, wherein
R 9 , R 10 , and R 11 are independently selected from the group consisting of hydrogen, halogen, acetoxy, lower alkyl, lower haloalkyl, lower haloalkoxy, aryl, and lower alkoxy;
R 12 is a bond or; and
R 13 is selected from the group consisting of methyl, —C(CH 3 ) 3 , —NHC(CH 3 ) 3 , —C≡N, Hydroxyl,
wherein R 14 is selected from the group consisting of hydrogen, halogen, acetoxy, lower alkyl, lower haloalkyl, lower haloalkoxy, aryl, and lower alkoxy and n is an integer from 1 to 3.
2. The method of claim 1 wherein the compound is selected from the group consisting of:
3. A method according to claim 1 , wherein the Apicomplexan parasite is selected from the group consisting of Toxoplasma, Plasmodium, Eimeria, Theileria, Babesia, Sarcocystis, Cryptosporidium, Cydospora, Isospora , and Neospora.
4. The method of claim 3 , wherein the Apicomplexan parasite is selected from the group consisting of Plasmodium falciparum, Plasmodium vivax, Cryptosporidium parvum , and Cyclospora cayatanensis.
5. The method of claim 2 , wherein the compound is a compound of formula (VII):
6. The method of claim 2 , wherein the compound is a compound of formula (VIII):
7. The method of claim 3 , wherein the compound is a compound of formula (VII):
8. The method of claim 3 , wherein the compound is a compound of formula (VIII):