Compound capable of inhibiting 17-beta hydroxysteriod dehydrogenase

1. A compound having Formula

wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are independently selected from:

(a) H; (b) R 13 , —OC(R 13 ) 3 , —OCH(R 13 ) 2 , —OCH 2 R 13 , —C(R 13 ) 3 , —CH(R 13 ) 2 , or —CH 2 R 13 wherein R 13 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl;

(h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl;

(j) hydroxy; (k) alkoxy; (l) aryloxy; (m)-SO 2 -alkyl; or (n) —N(R 14 )C(O)R 15 ,

wherein R 14 and R 15 are independently selected from H; an alkyl group, an alkenyl group, an alkynyl group, any of which may be linear, branched or cyclic; or an aryl group, wherein the optional substituents of (d), (e), (f), (h), and (i) are C 1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C 1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl or heteroaryl;

wherein n and p are 0;

X is O,

R 10 is selected from H, alkyl, or acyl groups,

R 11 is selected from CR 19 R 20 , in which R 19 and R 20 are independently selected from H, alkyl, alkenyl or alkylaryl groups,

R 12 is selected from a substituted five or six membered carbon rings optionally comprising one or more hetero atoms selected from N, S, or O and optionally having fused thereto a further ring, and wherein the one or more substituent is at least selected from an amide group.

2. The compound of claim 1 wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are independently selected from

(a) H or

(b) R 13 , —OC(R 13 ) 3 , —OCH(R 13 ) 2 , —OCH 2 R 13 , —C(R 13 ) 3 , —CH(R 13 ) 2 , or —CH 2 R 13 , wherein R 13 is a halogen.

3. The compound of to claim 1 wherein R 13 is Cl or F.

4. The compound of claim 1 wherein (b) is F, Cl, —OCF 3 , —OCHF 2 , —OCH 2 F, —CF 3 , —CHF 2 , or —CH 2 F.

5. The compound of claim 1 wherein (b) is F, Cl or OCF 3 .

6. The compound of claim 1 wherein R 1 is H or Cl.

7. The compound of claim 1 wherein R 2 is H.

8. The compound of claim 1 wherein R 3 is Cl or OCF 3 .

9. The compound of claim 1 wherein R 4 is H.

10. The compound of claim 1 wherein R 5 is H.

11. The compound of claim 1 wherein R 6 is H.

12. The compound of claim 1 wherein R 7 is H.

13. The compound of claim 1 wherein R 8 is H or F.

14. The compound of claim 1 wherein R 1 is H or Cl, R 3 is Cl or OCF 3 , R 8 is H or F, and R 2 , R 4 , R 5 , R 6 and R 7 are each H.

15. The compound of claim 1 wherein R 10 is H, methyl (—CH 3 ) or acetyl (—CO—CH 3 ) groups.

16. The compound of claim 1 wherein R 19 and R 20 are independently selected from H, C 1-6 alkyl, C 1-6 alkenyl or C 1-6 alkyl phenyl groups.

17. The compound of claim 1 wherein R 19 and R 20 are independently selected from H, —CH 3 , —CH 2 CH 2 CH 3 , —CH 2 CH═CH 2 , or —CH 2 -Ph.

18. The compound of claim 1 wherein R 20 is H and R 19 is H, —CH 3 , —CH 2 CH 2 CH 3 , —CH 2 CH═CH 2 , or —CH 2 -Ph.

19. The compound of claim 1 wherein R 20 is H and R 19 is —CH 3 , —CH 2 CH 2 CH 3 , —CH 2 CH═CH 2 , or —CH 2 -Ph.

20. The compound of claim 1 wherein R 12 is a substituted aryl ring, optionally having fused thereto a further ring.

21. The compound of claim 1 wherein R 12 is a substituted carbocyclic ring, optionally having fused thereto a further ring.

22. The compound of claim 1 wherein R 12 is a substituted six membered carbocyclic ring, optionally having fused thereto a further ring.

23. The compound of claim 1 wherein R 12 is a substituted phenyl ring, optionally having fused thereto a further ring.

24. The compound of claim 1 wherein the optional fused ring of R 12 is selected from a substituted five or six membered carbon rings optionally comprising one or more hetero atoms of N, S, or O.

25. The compound of claim 1 wherein the R 12 is a substituted five or six membered carbon rings, wherein the one or more substituents are at least selected from amide groups.

26. The compound of claim 25 wherein the one or more substituents are at least selected from —NR 21 —CO—R 22 , wherein R 21 and R 22 are independently selected from H, phenyl or C 1-10 alkyl groups.

27. The compound of claim 25 wherein the one or more substituents are at least selected from —NR 21 —CO—R 22 , wherein R 21 and R 22 are independently selected from H, phenyl or C 1-10 alkyl groups.

28. The compound of claim 26 wherein R 21 and R 22 are independently selected from H, methyl or phenyl.

29. The compound according to claim 25 wherein the one or more substituents are at least selected from —NH—CO-Me.

30. The compound of claim 1 wherein the compound is of Formula II

31. The compound of claim 1 wherein the compound is of Formula III

32. The compound of claim 1 wherein the compound is of Formula IV

33. The compound of claim 1 wherein the compound is of Formula V

34. The compound of claim 1 wherein the compound is of Formula VI

35. The compound of claim 1 wherein the compound is of Formula VII

36. The compound of claim 1 wherein the compound is of Formula VIII

37. A pharmaceutical composition comprising a compound of claim 1 optionally admixed with a pharmaceutically acceptable carrier, diluent, excipient or adjuvant.

38. A medicinal compound comprising the compound of claim 1 .

39. The compound of claim 27 wherein R 21 and R 22 are independently selected from H, phenyl or C 1-10 alkyl groups.

40. The compound of claim 27 wherein R 21 and R 22 are independently selected from H, methyl or phenyl.

41. The compound of claim 1 , wherein R 12 further comprises one or more alkyl group, alkoxy group, or halogen.

42. A compound having a formula of

43. A pharmaceutical composition comprising a compound of claim 42 optionally admixed with a pharmaceutically acceptable carrier, diluent, excipient or adjuvant.

44. A medicinal compound comprising the compound of claim 42 .