Treatment of cardiac arrhythmias
View Patent ↗Compositions of the invention, including compounds that bind to a receptor for a glucagon-like peptide-1, an incretin, a glucagon-like peptide-1 (GLP-1), an exendin, or an agonist, an analog (preferably an agonist analog), a derivative, or a variant of any of aforementioned compounds, are used in the prevention and treatment of arrhythmias associated with cardiac ischemia, cardiac ischemia-perfusion and/or congestive heart failure. The invention relates to both the method and compositions for such treatment.
1. A method for treating arrhythmias comprising:
administering to an individual in need of such treatment an amount of a composition effective to treat arrhythmias,
said composition comprising an exendin or exendin analog of SEQ ID NO: 25 or SEQ ID NO: 26 that binds to a receptor for GLP-1; and
thereby treating said arrhythmias.
2. The method of claim 1 wherein the exendin or exendin analog is SEQ ID NO: 14 or 19-24.
3. The method of claim 1 wherein the composition is administered in a dose of from about 0.01 pmol/kg to 20 nmol/kg.
4. The method of claim 1 wherein the composition is administered concurrently with a member of the group consisting of: glucose, potassium, and a free radical scavenger.
5. The method of claim 1 wherein the composition is administered within four hours of an ischemic event.
6. The method of claim 5 wherein the composition continues to be administered following the ischemic event.
7. The method of claim 1 wherein the composition is administered concurrently or as soon as possible following therapies that reestablish flow in an artery that has been obstructed.
8. The method of claim 1 wherein the composition is administered to treat ventricular arrhythmias.
9. The method of claim 8 wherein the ventricular arrhythmia is caused by a condition selected from the group consisting of cardiac ischemia, cardiac ischemia-reperfusion, and congestive heart failure.
10. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 14.
11. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 19.
12. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 20.
13. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 21.
14. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 22.
15. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 23.
16. The method of claim 2 wherein the exendin or exendin analog is SEQ ID NO: 24.
17. A method for treating arrhythmias comprising:
administering to an individual in need of such treatment an amount of a composition effective to treat arrhythmias,
said composition comprising exendin-4; and
thereby treating said arrhythmias.