Hetero-substituted acetanilide derivatives as analgesic agents
Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.
1. A method of controlling pain or fever in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
wherein R 3 is hydrogen and R 1 and R 2 taken together form an optionally substituted selected from the group consisting of pyarazole, and imidazole;
R 4 is a hydrogen;
n is an integer from 1 to 3;
and enantiomers, diastereomers, tautomers, or pharmaceutically acceptable salts thereof.
2. The method of controlling pain or fever of claim 1 , wherein R 1 and R 2 taken together form an optionally substituted imidazole and enantiomers, diastereomers, tautomers, or pharmaceutically acceptable salts thereof.
3. A method of controlling pain or fever in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
5-Methyl-1H-pyrazole-3-carboxylic acid (4-hydroxy-phenyl)-amide; and
3H-Imidazole-4-carboxylic acid (4-hydroxy-phenyl)-amide;
and enantiomers, diastereomers, tautomers, or pharmaceutically acceptable salts thereof.
4. The method of controlling pain or fever of claim 3 , wherein the compound is 5-Methyl-1H-pyrazole-3-carboxylic acid (4-hydroxy-phenyl)-amide and enantiomers, diastereomers, tautomers, or pharmaceutically acceptable salts thereof.