IP Library › Patent Application 12751908
Patent Application
App. No. 12/751,908

DIAGNOSIS OF FETAL ANEUPLOIDY BY QUANTIFICATION OF GENOMIC DNA FROM MIXED SAMPLES

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Quick Facts
Patent No.
US None
App. No.
12/751,908
Abstract

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a determination and report a non-informative case. The present invention involves quantifying regions of genomic DNA from a mixed sample. More particularly the invention involves quantifying DNA polymorphisms from the mixed sample.

Claims (5)

1 . A method for diagnosing a fetal abnormality comprising:

obtaining a maternal blood sample,

enriching one or more fetal cells from said sample using size-based separation,

analyzing one or more regions of genomic DNA from said fetal cells for STRs, and

determining a fetal abnormality based on the STR analysis.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 6, 2012
From: STOUGHTON, ROLAND; KAPUR, RAVI; COHEN, BARB ARIEL
To: LIVING MICROSYSTEMS, INC.
Reel/Frame 027816/0087 →
CHANGE OF NAME Recorded Mar 6, 2012
From: LIVING MICROSYSTEMS, INC.
To: ARTEMIS HEALTH, INC.
Reel/Frame 027824/0100 →
CHANGE OF NAME Recorded Mar 6, 2012
From: ARTEMIS HEALTH, INC.
To: VERINATA HEALTH, INC.
Reel/Frame 027824/0113 →