IP Library › Granted Patent US 9,057,736
Granted Patent B2
US 9,057,736 · App. 12/755,146 · Granted Jun 16, 2015

Markers associated with arteriovascular events and methods of use thereof

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Quick Facts
Patent No.
US 9,057,736
App. No.
12/755,146
Granted
Jun 16, 2015
Kind
B2
Abstract

Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with arteriovascular disease from other diseases or within sub-classifications of arteriovascular disease, methods of evaluating the risk of arteriovascular events in patients with arteriovascular disease, methods of evaluating the effectiveness of treatments in subjects with arteriovascular disease, and methods of selecting therapies for treating arteriovascular disease.

Claims (10)

1. A method for evaluating the risk of a cardiovascular event for a subject comprising:

measuring a panel of at least biomarker CRP, ICAM-1, and age, and

using a value calculated from a linear combination of the measurements of the panel to evaluate the risk of a cardiovascular event.

2. The method of claim 1 , wherein the risk evaluation comprises calculating an index value.

3. The method of claim 2 , wherein the index value is correlated with the risk of a cardiovascular event.

4. The method of claim 1 , wherein the risk evaluation comprises normalizing the biomarker measurements to reference values.

5. The method of claim 1 , wherein the measurement of at least one of the biomarkers of the panel is unaffected by treatment of the subject with one or more therapeutic interventions.

6. The method of claim 1 , wherein the measurement of at least one of the biomarkers of the panel is affected by treatment of the subject with one or more therapeutic interventions.

7. The method of claim 1 , further comprising measuring one or more clinical parameters chosen from body mass index (BMI), diabetes, diastolic blood pressure (DBP), family history (FamHX), hip (circumference), height (HT), ethnicity (RACE), systolic blood pressure (SBP), gender (SEX), smoking, waist (circumference), and weight (WT).

8. The method of claim 1 , further comprising one or more additional biomarker chosen from POMC, HDLC, and VEGF.

Assignments (8)
SECURITY INTEREST Recorded Jan 31, 2017
From: TRUE HEALTH IP LLC
To: MONROE CAPITAL MANAGEMENT ADVISORS, LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 041575/0879 →
RELEASE OF SECURITY INTEREST Recorded Jan 19, 2017
From: CVF BEADSEA LLC, AS COLLATERAL AGENT
To: HEALTH DIAGNOSTIC LABORATORY, INC.; INTEGRATED HEALTH LEADERS, LLC
Reel/Frame 041013/0469 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 23, 2016
From: TRUE HEALTH DIAGNOSTICS, LLC
To: TRUE HEALTH IP LLC
Reel/Frame 040412/0146 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2016
From: HEALTH DIAGNOSTIC LABORATORY, INC.
To: TRUE HEALTH DIAGNOSTICS, LLC
Reel/Frame 037784/0683 →
SECURITY INTEREST Recorded Aug 10, 2015
From: HEALTH DIAGNOSTIC LABORATORY, INC.; INTEGRATED HEALTH LEADERS, LLC
To: CVF BEADSEA LLC, AS COLLATERAL AGENT
Reel/Frame 036292/0164 →
RELEASE OF SECURITY INTEREST Recorded Jun 10, 2014
From: HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
To: TETHYS BIOSCIENCE, INC.
Reel/Frame 033114/0137 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 6, 2014
From: TETHYS BIOSCIENCE, INC.
To: HEALTH DIAGNOSTIC LABORATORY, INC.
Reel/Frame 031894/0337 →
SECURITY AGREEMENT Recorded Jul 5, 2012
From: TETHYS BIOSCIENCE, INC.
To: HERCULES TECHNOLOGY GROWTH CAPITAL, INC.
Reel/Frame 028503/0289 →