Inhibition of pathogens by probiotic bacteria
Compositions containing a lactic acid-producing bacterial strain, e.g., Bacillus coagulans for inhibition of pathogenic bacterial infections. Spores or extracellular products produced by the bacterial strains are also useful as inhibitory agents.
1. A method of maintaining gastrointestinal tract health comprising administering to the gastrointestinal tract of a mammal a composition comprising an isolated Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086), wherein said strain colonizes the gastrointestinal tract of said mammal to maintain gastrointestinal health.
2. The method of claim 1 , wherein said composition is administered orally, buccally, or nasally.
3. The method of claim 1 , wherein said composition is administered in a food or as a food supplement.
4. The method of claim 1 , wherein said strain produces lactic acid and has an optimal growth temperature of in the range of 25-35° C.
5. The method of claim 1 , wherein said strain produces lactic acid and has an optimal growth temperature of 30° C.
6. The method of claim 1 , wherein said strain produces L(+) dextrorotatory lactic acid and produces spores resistant to temperatures of up to approximately 90° C.
7. The method of claim 1 , wherein said composition comprises a viable Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086) vegetative bacterial cell.
8. The method of claim 1 , wherein said composition comprises a viable Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086) bacterial spore.
9. The method of claim 1 , wherein said composition comprises 1×10 3 to 1×10 14 CFU of Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).
10. The method of claim 1 , wherein said composition comprises 1×10 8 to 1×10 10 CFU of Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).
11. The method of claim 1 , wherein said composition comprises 1×10 9 CFU of Bacillus coagulans GBI-30 strain (ATCC Designation Number PTA-6086).