Polymeric quaternium compounds
View Patent ↗A topical pharmaceutical composition comprising a pharmaceutical active and a polymer of general formula I or general formula II wherein C k is a saturated or unsaturated, five, six or seven-membered ring; R is a C 1 -C 3 alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000.
1. A contact lens care solution comprising 0.5 ppm to 30 ppm of a polymer of general formula I
wherein C k is selected from the group consisting of phenyl, cyclohexyl, cyclohexene, and cyclopentyl;
R is a C 1 -C 3 alkyl; n is 1, 2, 3, 4 or 5 and m provides a number average molecular weight of the polymer of from 2000 to 80,000, and
a buffer system selected from a borate buffer system, a phosphate buffer system or TRIS, wherein the polymer of formula I is present as the sole antimicrobial component in the solution.
2. The ophthalmic composition of claim 1 wherein R is methyl.
3. The ophthalmic composition of claim 1 wherein C k is phenyl, R is methyl, and n is 1 or 2.
4. The ophthalmic composition of claim 1 wherein C k is phenyl, n is 1 and m provides a number average molecular weight of from 4000 to 40,000.
5. The lens care solution of claim 1 further comprising a biopolymer selected from the group consisting of hyaluronic acid, alginic acid, hydroxypropyl guar and hydroxypropylmethyl cellulose; and a nonionic surfactant selected from a poloxamer, poloxamine or a mixture of the two.
6. The lens care solution of claim 5 wherein the biopolymer is hyaluronic acid, the hyaluronic acid provided at a concentration of 0.005 wt. % to 0.05 wt. %.
7. The lens care solution of 5 wherein the number average molecular weight of the polymer of formula I is from 4000 to 24,000.
8. The lens care solution of 5 wherein the polymer of formula I is present in the composition at a concentration of 0.5 ppm to 10 ppm.
9. The lens care solution of 5 wherein the solution satisfies primary biocidal kill in that for a recommended disinfection period the number of bacteria recovered per mL is reduced by a mean value of not less than 3.0 logs, and the number of mold and yeast recovered per mL is reduced by a mean value of not less than 1.0 log within the recommended disinfection period.
10. The ophthalmic composition of claim 1 wherein the polymer of formula I is present in the composition at a concentration of 0.5 ppm to 10 ppm.