Device and method for destruction of cancer cells
The present invention provides devices and systems, as well as methods, of electric field delivery and non-thermal or selective ablation of target tissue regions, including selective ablation of cancerous cells and solid tumors. A method of the present invention includes delivering an electric field to a tissue, including positioning an electrode within a target tissue region comprising cancerous cells, and applying an alternating electrical current to the target tissue so as to non-thermally ablate cancerous cells of the target tissue region around the electrodes.
1. A system for non-thermal tissue ablation, comprising:
a tissue treatment probe having one or more elongate electrodes shaped for positioning or advancement within a target tissue region comprising cancerous cells; and
an energy source coupled to the probe and configured to cause the probe to apply an alternating electrical field of less than 50 V/cm to the target tissue region to non-thermally destroy cancerous cells of the target tissue region; and
a control system operatively connected to the energy source and the probe, the control system comprising:
one or more processors; and
memory, including instructions stored thereon that, when executed by the one or more processors, cause the control system to at least provide, via the one or more elongate electrodes when positioned in target tissue, the alternating electrical field through the target tissue region so as to non-thermally destroy the cancerous cells of the target tissue region around the electrodes, the electrical field comprising a frequency between about 50 kHz to about 300 kHz.
2. The system of claim 1 , wherein the energy source is powered by a battery.
3. The system of claim 1 , wherein the instructions cause the control system to further apply the electric field, via the one or more electrodes, in substantial alignment with a division axis of a dividing cancerous cell of the target tissue region.
4. The system of claim 1 , further comprising a feedback unit for detecting a characteristic of tissue of the target tissue region.
5. The system of claim 4 , wherein the characteristic comprises impedance or temperature.
6. The system of claim 1 , further comprising an imaging system.
7. The system of claim 1 , further comprising a computer configured to output a signal to the energy source for providing the alternating electrical field to the target tissue.
8. The system of claim 1 , further comprising a positioning system for holding the probe in a treatment position during energy delivery to the target tissue.
9. A system for selectively destroying cancerous cells, comprising:
a plurality of elongate, tissue penetrating electrodes positionable within a target tissue, the plurality comprising a first electrode and one or more secondary electrodes, a treatment volume at least partially definable by the secondary electrodes, with the first electrode positionable within the treatment volume;
an energy source coupled to the plurality of elongate electrodes to provide one or more alternating electric fields of less than 50 V/cm extending radially from the first electrode and through the treatment volume; and
a control system operatively connected to the energy source, the control system comprising:
one or more processors; and
memory, including instructions stored thereon that, when executed by the one or more processors, cause the control system to at least apply the one or more alternating electric fields to the treatment volume, where the electrodes are positioned such that the treatment volume is at least partially defined by the secondary electrodes, so as to preferentially destroy the cancerous cells compared to non-cancerous cells within the treatment volume.
10. The system of claim 9 , wherein the energy source is powered by a battery.
11. The system of claim 9 , wherein the applied one or more alternating electrical fields provide non-thermal destruction of the cancerous cells within the treatment volume.
12. The system of claim 9 , wherein the instructions cause the control system to further apply at least one of the one or more alternating electrical fields in substantial alignment with division axes of dividing cancerous cells within the treatment volume.
13. The system of claim 9 , further comprising a computer coupled to the energy source to output a signal for a selected treatment one or more alternating electrical fields for application to the target tissue within the treatment volume.
14. The system of claim 13 , further comprising a user interface coupled to the computer.
15. The system of claim 9 , wherein the system comprises an ambulatory system.
16. The system of claim 9 , wherein an elongate electrode comprises an insulated portion and/or non-insulated portion.
17. The system of claim 16 , wherein the non-insulated portion of the electrode comprises an electric current delivery surface.
18. The system of claim 9 , wherein the instructions cause the control system to apply the one or more alternating electrical fields with the first electrode positioned substantially within the center of the treatment volume.
19. The system of claim 9 , wherein the system comprises an electrically floating system.
20. The system of claim 9 , wherein an electrode of the plurality comprises a shape memory metal.
21. The system of claim 9 , wherein the plurality of electrodes are coupled to a probe comprising a delivery member having a distal portion with a lumen, and the plurality of electrodes positionable within the lumen of the delivery member.
22. The system of claim 21 , wherein the plurality of electrodes comprising a non-deployed state with electrodes positioned within the lumen of the delivery member, and a deployed state with electrodes advanced from the distal portion of the delivery member.
23. The system of claim 22 , wherein the treatment volume is defined by electrodes in the deployed state.
24. The system of claim 9 , wherein the electrodes each comprising a tissue piercing distal portion for percutaneous access to the target tissue.
25. The system of claim 9 , wherein the secondary electrodes comprise a plurality of straight needle electrodes disposed in an arrangement equally spaced from a central first needle electrode, the secondary electrodes defining a cylindrical treatment volume.
26. The system of claim 9 , wherein the secondary electrodes are curved so as to define a substantially spherical treatment volume.
27. The system of claim 9 , wherein the instructions cause the control system to further apply the one or more alternating electrical fields such that heating of the target tissue is about 10 degrees C. above body temperature or less.