Anti-viral compounds

1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,

wherein:

A is

 B is

 Z 1 is independently selected at each occurrence from O, S, NH or CH 2 , Z 2 is independently selected at each occurrence from N or CH, wherein A and B are each independently optionally substituted with one or more R A ;

D is C 3 -C 10 carbocycle or 3- to 10-membered heterocycle, and is optionally substituted with one or more R A ; or D is selected from C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, and is optionally substituted with one or more substituents selected from halogen, R T , —O—R S , —S—R S , —N(R S R S ′), —OC(O)R S , —C(O)OR S , nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano;

X is N;

L 1 and L 2 are —(CH 2 )—, and are each independently optionally substituted with one or more substituents selected from halogen, R T , —O—R S , —S—R S , —N(R S R S ′), —OC(O)R S , —C(O)OR S , nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano;

L 3 is bond;

Y is selected from —C(R 1 R 2 )N(R 5 )-T-R D Or —C(R 3 R 4 )C(R 6 R 7 )-T-R D ;

R 1 is R C , and R 2 and R 5 , taken together with the atoms to which they are attached, form a 3- to 8-membered heterocyclic ring which is optionally substituted with one or more R A ;

R 3 and R 6 are each independently R C , and R 4 and R 7 , taken together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic or heterocyclic ring which is optionally substituted with one or more R A ;

Z is selected from —C(R 8 R 9 )N(R 12 )-T-R D or —C(R 10 R 11 )C(R 13 R 14 )-T-R D ;

R 8 is R C , and R 9 and R 12 , taken together with the atoms to which they are attached, form a 3- to 8-membered heterocyclic ring which is optionally substituted with one or more R A ;

R 10 and R 13 are each independently R C , and R 11 and R 14 ,taken together with the atoms to which they are attached, form a 3- to 8-membered carbocyclic or heterocyclic ring which is optionally substituted with one or more R A ;

T is each independently selected at each occurrence from a bond, -L S -, -L S -M-L S ′-, -L S -M-L S ′-M′-L S ″-, wherein M and M′ are each independently selected at each occurrence from a bond, —O—, —S—, —N(R B )—, —C(O)—, —S(O) 2 —, —S(O)—, —OS(O)—, —OS(O) 2 —, —S(O) 2 O—, —S(O)O—, —C(O)O—, —OC(O)—, —OC(O)O—,—C(O)N(R B )—, —N(R B )C(O)—, —N(R B )C(O)O—, —OC(O)N(R B )—, —N(R B )S(O)—, —N(R B )S(O) 2 —, —S(O)N(R B )—, —S(O) 2 N(R B )—, —C(O)N(R B )C(O)—, —N(R B )C(O)N(R B ′)—, N(R B )SO 2 N(R B ′)—, —N(R B )S(O)N(R B ′)—, C 3 -C 10 carbocycle, or 3- to 10-membered heterocycle, and wherein said C 3 -C 10 carbocycle and 3- to 10-membered heterocycle are each independently optionally substituted at each occurrence with one or more R A ;

R A is independently selected at each occurrence from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, -L A, or -L S -R E ;

R B and R B ′ are each independently selected at each occurrence from hydrogen or R F ;

R C is independently selected at each occurrence from hydrogen, halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, or R F ;

R D is each independently selected at each occurrence from hydrogen or R A ;

R E is independently selected at each occurrence from —O—R S , —S—R S , —C(O)R S , —OC(O)R S , —C(O)OR S , —N(R S R S ′),—S(O)R S , —SO 2 R S , —C(O)N(R S R S ′), —N(R S )C(O)R S ′,—N(R S )C(O)N(R S ′R S ″), —N(R S )SO 2 R S ′, —SO 2 N(R S R S ′), —N(R S )SO 2 N(R S ′R S ″), —N(R S )S(O)N(R S ′R S ″), —OS(O)—R S , —OS(O) 2 —R S , —S(O) 2 OR S , —S(O) 2 OR S , —OC(O)OR S , —N(R S )C(O)OR S ′, —OC(O)N(R S R S ′), —N(R S )S(O)—R S ′, —S(O)N(R S R S ′), —C(O)N(R S )C(O)—R S ′, C 3 -C 10 carbocyclyl, or 3- to 10-membered heterocyclyl, wherein said C 3 -C 10 carbocyclyl and 3- to 10-membered heterocyclyl are each independently optionally substituted at each occurrence with one or more substituents selected from halogen, R T , —O—R B , —S—R B , —N(R B R B ′),—OC(O)R B , —C(O)OR B , nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano;

R F is independently selected at each occurrence from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 carbocyclyl, C 3 -C 6 carbocyclylC 1 -C 6 alkyl, 3- to 6-membered heterocyclyl or (3- or 6-membered heterocyclyl)C 1 -C 6 alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano;

L A is independently selected at each occurrence from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, or C 2 -C 6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, R T , —O—R S , —S—R S , —N(R S R S ′), —OC(O)R S , —C(O)OR S , nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano;

L S , L S ′ and L S ″ are each independently selected at each occurrence from a bond; or C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, R T , —O—R S , —S—R S , —N(R S R S ′), —OC(O)R S , —C(O)OR S , nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano;

R S , R S ′ and R S ″ are each independently selected at each occurrence from hydrogen or R T ;

R T is independently selected at each occurrence from C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 3 -C 6 carbocyclyl, C 3 -C 6 carbocyclylC 1 -C 6 alkyl, 3- to 6-membered heterocyclyl, or (3- or 6-membered heterocyclyl)C 1 -C 6 alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, R F , —O—R B , —S—R B , —N(R B R B ′), —OC(O)R B ,—C(O)OR B , nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano.

2. The compound or salt of claim 1 , wherein:

Z 1 is NH, and Z 2 is N;

T is independently selected at each occurrence from —C(O)-L S ′-M′-L S ″- or —N(R B )C(O)-L S ′-M′-L S ″-; and

L S ′ is independently C 1 -C 6 alkylene, and is independently optionally substituted at each occurrence with one or more substituents selected from halogen, R T , —O—R S , —S—R S , —N(R S R S ′), —OC(O)R S , —C(O)OR S , nitro, phosphonoxy, phosphono, oxo, thioxo, formyl or cyano.

3. The compound or salt of claim 1 , wherein:

Z 1 is NH, and Z 2 is N;

Y is 13 C(R 1 R 2 )N(R 5 )-T-R D ;

Z is —C(R 8 R 9 )N(R 12 )-T-R D ;

T is independently selected at each occurrence from —C(O)-L S ′-M′-L S ″-; and

D is C 5 -C 6 carbocycle, 5- to 6-membered heterocycle, or 6- to 10-membered bicycles, and is substituted with one or more R M , where R M is halogen, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano, or -L S -R E .

4. The compound or salt of claim 3 , wherein T is independently selected at each occurrence from —C(O)-L S ′-N(R B )C(O)-L S ″- or —C(O)-L S ′- N(R B )C(O)O-L S ″-.

5. The compound or salt of claim 3 , wherein R A is halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, cyano; or C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl or cyano; or C 3 -C 6 carbocycle or 3- to 6-membered heterocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, oxo, phosphonoxy, phosphono, thioxo, formyl, cyano, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, C 2 -C 6 haloalkenyl or C 2 -C 6 haloalkynyl.