Combinational chemotherapy treatment
View Patent ↗Disclosed is a composition comprising a therapeutically effective amount of (a) at least one compound from the group of 5-fluorouracil, 5-fluorodeoxyuridine, capecitabine or a prodrug of such compounds; and (b) 5-hydroxymethyl-2′-deoxyuridine, or a prodrug of such compound, as well as kits comprising such composition and methods of use thereof for treating neoplasia.
1. A method of treating neoplasia in a patient in need thereof, said method comprising administering to said patient a therapeutically effective amount of:
a) at least one compound selected from the group consisting of 5-Fluorouracil, 5-Fluorodeoxyuridine and capecitabine or other prodrug of 5-fluorouracil; and
b) 5-hydroxymethyl-2′-deoxyuridine, or a prodrug thereof.
2. The method of claim 1 , wherein said compounds of a) and b) are administered sequentially.
3. The method of claim 1 , wherein said compounds of a) and b) are administered simultaneously.
4. The method of claim 1 , wherein said neoplasia is a solid or liquid tumor.
5. The method of claim 4 , wherein said solid tumor is selected from the group consisting of colon cancer, pancreatic cancer and lung cancer.
6. The method of claim 1 , wherein said neoplasia is a refractory tumor.
7. The method of claim 1 , further comprising an agent selected from the group consisting of microtubule-stabilizing agents, microtubule-disruptor agents, alkylating agents, anti-metabolites, epidophyllotoxins, antineoplastic enzymes, topoisomerase inhibitors, inhibitors of cell cycle progression, and platinum coordination complexes.
8. The method of claim 1 , consisting of the administration of 5-Fluorouracil and 5-hydroxymethyl-2′-deoxyuridine.
9. The method of claim 1 , consisting of the administration of 5-Fluorodeoxyuridine and 5-hydroxymethyl-2′-deoxyuridine.
10. A composition comprising:
a) at least one of the compounds selected from the group consisting of 5-Fluorouracil, 5-Fluorodeoxyuridine and capecitabine or other prodrug of 5-fluorouracil; and
b) 5-hydroxymethyl-2′-deoxyuridine or a prodrug thereof and a pharmaceutically acceptable carrier.
11. A composition comprising heterodinucleoside phosphates consisting of 5-Fluorodeoxyuridine and 5-hydroxymethyl-2′-deoxyuridine.
12. A kit for the treatment of neoplasia comprising the composition of claim 10 .
13. The kit of claim 12 , further comprising buffers, containers, and instructional materials.