IP Library › Granted Patent US 8,604,172
Granted Patent B2
US 8,604,172 · App. 12/761,584 · Granted Dec 10, 2013

Humanized antibody compositions and methods for binding lysophosphatidic acid

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Quick Facts
Patent No.
US 8,604,172
App. No.
12/761,584
Granted
Dec 10, 2013
Kind
B2
Abstract

Compositions and methods for making and using humanized anti-LPA monoclonal antibodies, and fragments and derivatives thereof, are described.

Claims (5)

1. An antibody or antigen-binding antibody fragment that binds lysophosphatidic acid (LPA) under physiological conditions, wherein each immunoglobulin heavy chain variable domain comprises the amino acid sequence of SEQ ID NO: 189 and each immunoglobulin light chain variable domain comprises the amino acid sequence of SEQ ID NO: 169.

2. An antibody or antigen-binding antibody fragment according to claim 1 that is selected from the group consisting of a full-length antibody or an Fab fragment.

3. An antibody or antigen-binding antibody fragment according to claim 1 that is a monoclonal antibody or an antigen-binding antibody fragment of a humanized antibody.

4. An antibody or antigen-binding antibody fragment according to claim 1 that is a humanized antibody or an antigen-binding antibody fragment of a humanized antibody.

5. A composition comprising a pharmaceutically acceptable carrier and an antibody or antigen-binding antibody fragment according to claim 1 .

Assignments (4)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 048622/0358 →
CHANGE OF NAME Recorded Mar 27, 2017
From: LPATH, INC.
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 042097/0896 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0766 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2013
From: SABBADINI, ROGER A.; GARLAND, WILLIAM A.; HANSEN, GENEVIEVE; JONES, STEVEN TARRAN; WILLIAMS, DAVID GARETH
To: LPATH, INC.
Reel/Frame 030851/0224 →