Freeze-dried molded article containing magnesium ascorbyl phosphate
The invention relates to freeze-dried molded articles containing magnesium ascorbyl phosphate and alginate as well as optionally one or more active substances and/or auxiliary substances. Furthermore, the invention relates to methods for manufacturing these freeze-dried molded articles, the combination of such freeze-dried molded articles in kit-of-parts arrangements together with aqueous solutions, as well as the use of the freeze-dried molded articles and the kit-of-parts combinations for pharmaceutical and cosmetic application.
1. A freeze-dried molded article comprising:
(a) 10-25 wt-% magnesium ascorbyl phosphate;
(b) 25-80 wt-% of a pharmaceutical or cosmetic oil selected from the group consisting of jojoba oil, squalene oil, caprylic/capric acid tryglycerides, and mixtures thereof; and
(c) 20-40 wt-% calcium-free sodium alginate;
wherein the molded article decomposes completely without mechanical influence within ≦30 seconds when added to water, and wherein the freeze-dried molded article does not comprise a maleic acid copolymer.
2. The freeze-dried molded article according to claim 1 , further comprising one or more active substances.
3. The freeze-dried molded article according to claim 2 , wherein at least one of the one or more pharmaceutically or cosmetically active substances is selected from the group consisting of vitamins and their derivatives.
4. The freeze-dried molded article according to claim 3 , wherein the pharmaceutically or cosmetically active substance is selected from the group consisting of vitamin C (ascorbic acid) and its derivatives.
5. The freeze-dried molded article according to claim 2 , wherein the one or more pharmaceutically or cosmetically active substances is selected from the group consisting of vitamin C (ascorbic acid) and its derivatives.
6. The freeze-dried molded article according to claim 1 , whose 1% by wt, solution or suspension in water, at 20° C., has a pH value ≧4.0.
7. The freeze-dried molded article according to claim 6 , whose 1% by wt, solution or suspension in water, at 20° C., has a pH value ≧5.0.
8. The freeze-dried molded article according to claim 7 , whose 1% by wt. solution or suspension in water, at 20° C., has a pH value ≧6.0.
9. The freeze-dried molded article according to claim 1 , which decomposes completely within ≦20 seconds when water is added.
10. The freeze-dried molded article according to claim 9 , which decomposes completely within ≦10 seconds when water is added.
11. The freeze-dried molded article according to claim 10 , which decomposes completely within ≦5 seconds when water is added.
12. The freeze-dried molded article according to claim 1 , wherein the molded article contains ≧20% by wt. magnesium ascorhyl phosphate, based on the total weight of the freeze-dried molded article.