SYRINGE SYSTEM FOR CONTROLLED DELIVERY OR REMOVAL OF MATERIAL
Embodiments disclosed herein relate to syringe systems for delivering and removing materials, instrument kits that include the syringe systems provided herein, and methods of using the syringe systems and kits provided herein.
1 . A syringe delivery system, comprising:
a hollow handle;
a syringe plunger assembly;
a syringe barrel comprising flanges;
a driving mechanism comprising a thumbwheel portion and a gear portion, wherein said driving mechanism actuates the syringe plunger through a driving system, and;
an adaptor fitting that attaches the syringe barrel to the handle, wherein said adaptor fitting prevents longitudinal motion of the syringe barrel by securing the flanges of the syringe barrel;
wherein said syringe plunger is held substantially within the handle when the syringe barrel is filled, and further wherein said system is configured to deliver multiple microdroplets of a fluid to separate areas of tissue in a subject during a single procedure, or to extract said fluid from a subject during a procedure, wherein said fluid comprises a filler or a restorative agent suitable for a reconstructive or a cosmetic procedure.
2 . The syringe delivery system of claim 1 , wherein said filler or restorative agent is a composition comprising adipose-derived regenerative cells, adipose tissue, adipocytes, an injectable collagen, a hyaluronic acid filler, a botulinum toxin, a poly-L-lactic acid filler, a calcium hydroxyapatite filler, a silicone filler, or a microparticle filler.
3 . The syringe delivery system of claim 1 , wherein said system is configured to dispense and extract material from a subject.
4 . The syringe delivery system of claim 1 , wherein the syringe plunger shaft, base and seal are disposable.
5 . The syringe delivery system of claim 1 , wherein the syringe barrel is disposable.
6 . The syringe delivery system of claim 5 , wherein the disposable syringe barrel comprises a standard disposable syringe.
7 . The syringe delivery system of claim 1 , wherein said system is configured to interchangeably accommodate syringe barrels of more than one size.
8 . The syringe delivery system of claim 1 , wherein said system is configured to interchangeably accommodate handles of more than one size.
9 . The syringe delivery system of claim 1 , wherein depression of said thumbwheel releases the driving system.
10 . The syringe delivery system of claim 1 , wherein the driving system comprises a rack and pinion mechanism.
11 . The syringe delivery system of claim 9 , wherein said release moves the rack in reverse by a set amount.
12 . The syringe delivery system of claim 1 , further comprising a sensor that is configured to detect the level of pressure or vacuum in the syringe barrel.
13 . The syringe delivery system of claim 12 , wherein said sensor activates an alarm when said pressure or vacuum exceeds an predetermined level.
14 . The syringe delivery system of claim 13 , wherein said sensor activates at a pressure level of 1 atm.
15 . The syringe delivery system of claim 13 , wherein said sensor activates at a vacuum level of −0.5 atm.
16 . The syringe delivery system of claim 1 , wherein said reconstructive or cosmetic procedure is selected from the group consisting of: tissue defect filling; breast augmentation; lip augmentation; wrinkle filling, and; filling of defects caused by injury, trauma, infection, and surgery.
17 . A method for delivering microdroplets of a filler or a restorative agent to a patient, or extracting microdroplets of a filler or a restorative agent from a patient in a reconstructive or cosmetic procedure comprising:
providing a syringe delivery system comprising:
a hollow handle;
a syringe plunger assembly;
a syringe barrel comprising flanges; and
a driving mechanism comprising a thumbwheel portion and a gear portion, wherein said driving mechanism actuates the syringe plunger through a rack and pinion arrangement, and; an adaptor fitting for attaching the syringe barrel to the handle, wherein said adaptor fitting prevents longitudinal motion of the syringe barrel by securing the flanges of the syringe barrel;
wherein said syringe plunger is held substantially within the handle when the syringe barrel is filled, and further wherein a first movement of said thumbwheel causes depression of said plunger into the syringe barrel, causing delivery of microdroplets of a fluid, and wherein a second movement of said thumbwheel causes entry of said microdroplets of fluid into said syringe barrel; performing said first movement or said second movement of said thumbwheel.
18 . The method of claim 17 , wherein said fluid is a filler or a restorative agent formulated for a reconstructive or cosmetic procedure.
19 . The method of claim 18 , wherein said filler or restorative agent is a composition comprising adipose-derived regenerative cells, adipose tissue, adipocytes, an injectable collagen, a hyaluronic acid filler, a botulinum toxin, a poly-L-lactic acid filler, a calcium hydroxyapatite filler, a silicone filler, or a microparticle filler.
20 . The method of claim 18 , wherein said reconstructive or cosmetic procedure is selected from the group consisting of: tissue defect filling; breast augmentation; lip augmentation; wrinkle filling, and; filling of defects caused by injury, trauma, infection, and surgery.