Pressure monitoring to control delivery of therapeutic agent
A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension includes introducing the therapeutic fluid to a patient via a catheter at a predetermined rate. The catheter is positioned to deliver the fluid to the right ventricle or the pulmonary artery. The catheter a one-way valve configured to allow the fluid to flow from the catheter to the target location. The method further includes monitoring pressure of the target location by monitoring internal catheter pressure, and adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure. The rate at which the fluid is introduced to the catheter is increased if internal catheter pressure increases, and the rate at which the fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
1. A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension, the therapeutic fluid being delivered from an implanted catheter to a target region of the patient into which the catheter is implanted, wherein at least a portion of the catheter is implanted in the right ventricle or the pulmonary artery of the patient, the method comprising:
introducing the therapeutic fluid to the catheter at a predetermined rate, the catheter having a delivery region implanted in the target location;
monitoring pressure of the right ventricle or the pulmonary artery by monitoring internal catheter pressure; and
adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure,
wherein the rate at which the therapeutic fluid is introduced to the catheter is increased if the internal catheter pressure increases, and
wherein the rate at which the therapeutic fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
2. A method for adjusting delivery of a therapeutic fluid to a patient suffering from or at risk of pulmonary arterial hypertension, the therapeutic fluid being delivered from an implanted catheter to a target region of the patient into which the catheter is implanted, wherein at least a portion of the catheter is implanted in the right ventricle or the pulmonary artery of the patient, the method comprising:
introducing the therapeutic fluid to the catheter at a predetermined rate, the catheter having a delivery region implanted in the target location, the delivery region having a one-way valve configured to allow the therapeutic fluid to flow from the catheter to the target location;
monitoring pressure of the right ventricle or the pulmonary artery by monitoring internal catheter pressure; and
adjusting the rate at which the therapeutic fluid is introduced to the catheter based on the monitored pressure, wherein the rate at which the therapeutic fluid is introduced to the catheter is increased if the internal catheter pressure increases, and wherein the rate at which the therapeutic fluid is introduced to the catheter is decreased if the internal catheter pressure decreases.
3. The method of claim 2 , wherein the delivery region of the catheter is implanted in the pulmonary artery.
4. The method of claim 2 , wherein the delivery region of the catheter is implanted in the right ventricle.
5. The method of claim 2 , further comprising delivering the therapeutic fluid to the catheter via an implantable infusion device operably coupled to the catheter.
6. The method of claim 5 , wherein the implantable infusion device comprises an access port in fluid communication with the catheter, and wherein monitoring pressure of the catheter comprises detecting pressure via the access port.
7. The method of claim 5 , wherein monitoring the internal catheter pressure comprises measuring pressure of the therapeutic fluid via a pressure sensor disposed in the implantable infusion device.
8. The method of claim 7 , further comprising transmitting information regarding the pressure of the therapeutic fluid from the implantable infusion device to a first device external to the patient.
9. The method of claim 8 , wherein the first device external to the patient is configured to connect to a network.
10. The method of claim 8 , further comprising transmitting instructions regarding a new flow rate to the implantable infusion device from the first device external to the patient, wherein adjusting the flow rate comprises executing the instructions.
11. The method of claim 10 , wherein the first device is a programmer device.
12. The method of claim 8 , further comprising transmitting instructions regarding a new flow rate to the implantable infusion device from a second device external to the patient, wherein adjusting the flow rate comprises executing the instructions.