Treatment of osteoarthritis pain
View Patent ↗This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H 3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.
1. A method of treatment of osteoarthritis pain comprising administration of a histamine H 3 receptor antagonist, a salt thereof, or a composition comprising such histamine H 3 receptor antagonist or salt, to a mammal in need of treatment thereof, wherein the histamine H 3 receptor antagonist is 2-[4-((1S,2S)-2-{[(2S)-2-methylpyrrolidin-1-yl]methyl}cyclopropyl)phenyl]pyridazin-3(2H) one.
2. The method of claim 1 , wherein the histamine H 3 receptor antagonist is administered in a therapeutically effective amount with an effective amount of ibuprofen, celecoxib, or rofecoxib.
3. The method of claim 1 , wherein the histamine H 3 receptor antagonist is administered in an amount of 0.001 to 30 mg/kg of body weight.
4. The method of claim 1 , wherein the histamine H 3 receptor antagonist is administered in an amount of 1 mg/kg, 3 mg/kg or 10 mg/kg of body weight.