IP Library Granted Patent US 8,580,797
Granted Patent B2
US 8,580,797 · App. 12/768,777 · Granted Nov 12, 2013

Compounds

Inventors: Julie Nicole Hamblin (Stevenage, GB); Paul Spencer Jones (Stevenage, GB); Suzanne Elaine Keeling (Stevenage, GB); Joelle Le (Stevenage, GB); Nigel James Parr (Stevenage, GB)
Assignee: Glaxo Smith Kline Intellectual Property Development Limited
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Quick Facts
Patent No.
US 8,580,797
App. No.
12/768,777
Granted
Nov 12, 2013
Kind
B2
Abstract

The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Claims (9)

1. 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-indazole

or a salt thereof.

2. A compound according to claim 1 in the form of a pharmaceutically acceptable salt thereof.

3. 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hydrochloride

4. 6-(1H-Indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole

5. A pharmaceutical composition comprising a compound as claimed in claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

6. A pharmaceutical composition comprising 6-(1H-indol-4-yl)-4-(5-{[4-(1-methylethyl)-1-piperazinyl]methyl}-1,3-oxazol-2-yl)-1H-indazole hydrochloride, and one or more pharmaceutically acceptable excipients.

7. The compound according to claim 1 , wherein said compound is present in the form of a succinate salt.

8. A pharmaceutical compostion comprising the compound according to claim 7 , and one or more pharmaceutically acceptable excipients.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 31, 2014
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
To: GLAXO GROUP LIMITED
Reel/Frame 033452/0594 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2013
From: GLAXO GROUP LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 029821/0765 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2012
From: HAMBLIN, JULIE NICOLE; JONES, PAUL SPENCER; KEELING, SUZANNE ELAINE; LE, JOELLE; PARR, NIGEL JAMES
To: GLAXO GROUP LIMITED
Reel/Frame 027559/0848 →
Continuity (2)
Provisional Application 61174033 · Apr 30, 2009
Related Publication 20100280045A1 · Nov 4, 2010